Is protease profitable to sell on Amazon United States?

The niche generates $51K/yr across 27 tracked products. 0 of 1 products launched in the last 360 days are still selling. 90-day search growth is +9.6%. Flapen's verdict: Worth a look (50/100).

How competitive is the protease niche?

17 brands and 586 sellers compete. The top 5 products take 51% of clicks and top 5 brands hold 72% of demand.

What do buyers complain about in protease?

Top complaints mined from reviews: Functionality-Overall, Regulates Digestion, Acid Regulator/Stomach Ache Relief. The return rate is 0.0%.

When does demand for protease peak?

Demand is steady year-round — the busiest month runs 1.2× the quietest.

What does it cost to enter the protease niche?

Listings span $9.96–$86.87; the average listing price is $32.75 (sweet spot $15–$100). The average incumbent carries 3,641 reviews — the moat a new listing must climb.

protease

Worth a look

Shows low returns (0.0%), but a small market ($51K/yr) keeps it on the watch list.

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Avg price

Incredible$32.75

avg listing price — sweet spot $15–$100

Price range

Great$9.96–$86.87

cheapest to priciest tracked listing — scored on the share inside $15–$100

Competition

Good51%

top-5 click share — leaders hold, buyers still browse

Brand share

Good72%

top-5 brand share — brands hold most of the demand

Conversion

Okay3.9%

search→purchase rate — share of searches ending in a sale

Growth

Okay+9.6%

90-day search growth — must beat 0% to launch

Quality gap

Okay4.5★

avg incumbent rating — lower means beatable quality

Review moat

Okay3,641.11

avg incumbent reviews — the moat a new listing must climb

Market size

Bad$51K

$51K/yr · 40K searches

According to Flapen's Amazon United States niche tracking, protease is a $51K/yr Amazon United States market (40K searches/yr). The top 5 brands hold 72% of demand. Verdict: Worth a look — 50/100.

Data updated Jul 26, 2026 · scored weekly · How we score niches

protease market data

Units sold / yr: 2K–2K; avg 0–100/product
Revenue / yr: $49K–$66K; units × avg price
Conversion rate: 3.9%
Avg BSR: #713
Page quality: 0%
Prime: 96%
Sponsored: 81%
Out of stock: 0.0%
Avg brand age: 99 months
Avg seller age: 164 days

Competition & brand share

The top 5 products take 51% of clicks — established leaders, but buyers still shop beyond them.

Brands

17 falling

Sellers

586

Top-5 brand share

72%

Top 20: 100%

Top-5 click share

51%

Top 20: 93%

Open market

22%

TRANSFORMATION29%
NOW Foods19%
Physician's CHOICE9%
Pure Encapsulations8%
NESS7%
Double Wood Supplements6%

Demand & seasonality

Weekly Amazon search volume, last 102 weeks — +9.6% search growth over the last 90 days.

No pronounced peak months · busiest ÷ quietest = 1.2×

Open Trend

Top protease search terms

protease16K/yr +15.9%3.2% conv.
protease enzyme supplement13K/yr -6.5%5.6% conv.
protease enzyme4K/yr +143.3%2.4% conv.
amylase lipase protease enzyme3K/yr -2.3%4.3% conv.
protease enzymes4K/yr -53.8%2.2% conv.

All search terms

Top protease products on Amazon

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 24 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

TRANSFORMATION THE GENESIS OF GOOD HEALTH Protease 375K Enzyme Blend Supplement High-Potency Formula for Protein Absorption & Gut Health Advanced Enzym Support Non-GMO 60 Capsules

TRANSFORMATION$45.144.4★205 rev

NOW Supplements Pancreatin 10X 200 mg with naturally occurring Protease (Protein Digesting) Amylase (Carbohydrate Digesting) and Lipase (Fat Digesting) Enzymes 100 Capsules

NOW Foods$11.864.6★4,659 rev

Physicians CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16 Enzyme Formula with Organic Prebiotics & Probiotics for Gut & Digestive Health - Meal Time Discomfort Relief - 60 CT

Physician's CHOICE$19.084.5★18,747 rev

Ness Protease | Single Enzyme Digestive Supplement | Supports Protein Digestion | 180 Vegetarian Capsules

NESS$25.164.4★39 rev

TRANSFORMATION THE GENESIS OF GOOD HEALTH Enzymes - Protease Digestive Supplement Advanced Formula Supports Healthy Digestion Immunity Nutrient Absorption Improve Tolerance On an Empty Stomach

TRANSFORMATION$86.874.5★209 rev

Newest

by launch date

Digestive Enzymes Supplement for Men High Potency Pancreatin 4X Formula with Amylase Protease & Lipase Enzymes for Digestion Bloating Relief & Gut Health 50 Capsules

Vimerson Health$16.4927 rev

3mo ago

TRANSFORMATION THE GENESIS OF GOOD HEALTH Protease 375K Enzyme Blend Supplement High-Potency Formula for Protein Absorption & Gut Health Advanced Enzym Support for Nuttrient Absorption Non-GMO 120

TRANSFORMATION$82.21205 rev

2y ago

Physicians CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16 Enzyme Formula with Organic Prebiotics & Probiotics for Gut & Digestive Health - Meal Time Discomfort Relief - 60 CT

Physician's CHOICE$19.0818,747 rev

3y ago

Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase Lipase Bromelain Lactase Papain Protease Cellulase Maltase Invertase) by Double Wood

Double Wood Supplements$18.123,836 rev

5y ago

Wonder Laboratories Proteolytic Enzymes | Bromelain Papain Pancreatin Trypsin 550 mg Total with Standardized Amylase Lipase and Protease 100 Tablets

Wonder Laboratories$9.96787 rev

6y ago

What buyers say about protease

What buyers praise and complain about, mined from review topics.

What buyers love

Regulates Digestion32%

“Digestive aid”

Quality-Overall13%

“Good product and very effective”

Efficiency10%

“Works Well”

Acid Regulator/Stomach Ache Relief9%

“Great for indigestion”

Nutritional Content4%

“Great supplement”

Value For Money4%

“Good Price”

Advertised Vs Actual Product3%

“Works as advertised”

Vitamin2%

“Great supplement”

Ingredients-Overall1%

“They seem to have great ingredients”

Side Effects1%

“There was noticeably less discomfort when I took these”

What buyers complain about

Functionality-Overall15%

“they dont work very well”

Regulates Digestion12%

“had significant digestive discomfort every single time”

Acid Regulator/Stomach Ache Relief12%

“upsets your stomach”

Side Effects5%

“It made me nauseous”

Allergies4%

“Allergic to it”

Ingredients-Overall4%

“just too many unhealthy ingredients”

Dosage4%

“not good it doesnt do anything been take one capsule a day”

Pain Relief-Overall3%

“Terrible terrible pain”

Value For Money3%

“Expensive”

Nutritional Content2%

“NOT GLUTEN FREE”

Top return reasons

Functionality-Overall27%

Value For Money17%

Advertised Vs Actual Product8%

Color8%

Side Effects4%

Regulates Digestion4%

Smell4%

Stale/Rotten/Spoiled4%

Accuracy-Overall4%

Joint Pain4%

Common questions

Is protease profitable to sell on Amazon United States?: The niche generates $51K/yr across 27 tracked products. 0 of 1 products launched in the last 360 days are still selling. 90-day search growth is +9.6%. Flapen's verdict: Worth a look (50/100).
How competitive is the protease niche?: 17 brands and 586 sellers compete. The top 5 products take 51% of clicks and top 5 brands hold 72% of demand.
What do buyers complain about in protease?: Top complaints mined from reviews: Functionality-Overall, Regulates Digestion, Acid Regulator/Stomach Ache Relief. The return rate is 0.0%.
When does demand for protease peak?: Demand is steady year-round — the busiest month runs 1.2× the quietest.
What does it cost to enter the protease niche?: Listings span $9.96–$86.87; the average listing price is $32.75 (sweet spot $15–$100). The average incumbent carries 3,641 reviews — the moat a new listing must climb.