Is phosphatidylserine profitable to sell on Amazon United States?

The niche generates $2.9M/yr across 21 tracked products. 0 of 1 products launched in the last 360 days are still selling. 90-day search growth is -3.8%. Flapen's verdict: Worth a look (67/100).

How competitive is the phosphatidylserine niche?

14 brands and 30 sellers compete. The top 5 products take 60% of clicks and top 5 brands hold 63% of demand.

What do buyers complain about in phosphatidylserine?

Top complaints mined from reviews: Sleep Quality, Functionality-Overall, Value For Money. The return rate is 0.0%.

When does demand for phosphatidylserine peak?

Demand is steady year-round — the busiest month runs 1.4× the quietest.

What does it cost to enter the phosphatidylserine niche?

Listings span $14.75–$79.26; the average listing price is $32.51 (sweet spot $15–$100). The average incumbent carries 1,384 reviews — the moat a new listing must climb.

phosphatidylserine

Worth a look

Shows low returns (0.0%), but a failed launch gate (market size, growth, or returns) keeps it on the watch list.

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Market size

Incredible$2.9M

$2.9M/yr · 731K searches

Conversion

Incredible12.2%

search→purchase rate — share of searches ending in a sale

Avg price

Incredible$32.51

avg listing price — sweet spot $15–$100

Price range

Incredible$14.75–$79.26

cheapest to priciest tracked listing — scored on the share inside $15–$100

Brand share

Good63%

top-5 brand share — brands hold most of the demand

Review moat

Good1,383.57

avg incumbent reviews — the moat a new listing must climb

Competition

Okay60%

top-5 click share — leaders hold, buyers still browse

Quality gap

Okay4.5★

avg incumbent rating — lower means beatable quality

Growth

Bad-3.8%

90-day search growth — must beat 0% to launch

According to Flapen's Amazon United States niche tracking, phosphatidylserine is a $2.9M/yr Amazon United States market (731K searches/yr). The top 5 brands hold 63% of demand. Verdict: Worth a look — 67/100.

Data updated Jul 27, 2026 · scored weekly · How we score niches

phosphatidylserine market data

Units sold / yr: 80K–100K; avg 3,000–4,000/product
Revenue / yr: $2.6M–$3.3M; units × avg price
Conversion rate: 12.2%
Avg BSR: #1,216
Page quality: 0%
Prime: 100%
Sponsored: 71%
Out of stock: 4.3%
Avg brand age: 66 months
Avg seller age: 154 days

Competition & brand share

The top 5 products take 60% of clicks — established leaders, but buyers still shop beyond them.

Brands

14 falling

Sellers

Top-5 brand share

63%

Top 20: 92%

Top-5 click share

60%

Top 20: 99%

Open market

29%

Double Wood Supplements21%
Nutricost14%
NOW Foods11%
THORNE10%
--8%
Toniiq7%

Demand & seasonality

Weekly Amazon search volume, last 104 weeks — -3.8% search growth over the last 90 days.

No pronounced peak months · busiest ÷ quietest = 1.4×

Open Trend

Top phosphatidylserine search terms

phosphatidylserine490K/yr -1.0%10.2% conv.
phosphatidylserine supplement103K/yr -11.4%8.1% conv.
ps10017K/yr +12.0%8.0% conv.
phosphatidylserine 100mg18K/yr -21.2%8.8% conv.
phosphatidylserine 300mg17K/yr -35.0%10.4% conv.
fosfatidilserina13K/yr -7.3%2.5% conv.
phosphatidylserine 400mg5K/yr +163.1%11.7% conv.
phosphatidyl serine13K/yr -4.4%9.8% conv.
thorne phosphatidylserine9K/yr -1.6%17.9% conv.
phosphatidylserine 200mg7K/yr -34.5%8.8% conv.

All search terms

Top phosphatidylserine products on Amazon

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 21 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

PhosphatidylSerine Supplement 300mg Per Serving 120 Capsules (Phosphatidyl Serine Complex) by Double Wood

Double Wood Supplements$19.764.5★6,095 rev

Nutricost Phosphatidylserine (400mg) 120 Capsules Gluten Free

Nutricost$23.664.5★1,278 rev

THORNE - Phosphatidylserine - Supports Healthy Brain Function Memory & Focus - Helps Regulate Cortisol During Stress* - Third-Party Certified - Gluten-Free Dairy-Free - 60 Capsules

THORNE$66.374.5★273 rev

Phosphatidylserine Supplement 400mg Serving 240 Capsules Soy Free Sunflower Lecithin Source

--$24.174.6★1,348 rev

Toniiq Phosphatidylserine - 400mg Formula - Worlds First 50% Purity - Highest Purity in the US - Soy Free Phosphatidylserine Supplement - 90 Veggie Capsules

Toniiq$24.394.6★1,422 rev

Newest

by launch date

Micro Ingredients Phosphatidylserine 600 mg Per Serving 240 Capsules | Soy Free Phosphatidylserine Supplement with Choline Lions Mane Ginkgo & Omega-3 | Non-GMO Gluten Free

Micro Ingredients$21.8122 rev

6mo ago

Micro Ingredients Lions Mane+ with Omega-3 EPA DHA & Phosphatidylserine 240 Softgels with MCT Oil for Better Absorption Fruiting Body & Mycelium Superfood Mushroom Extract Lemon Flavored

Micro Ingredients$20.94123 rev

1y ago

ML Naturals Phosphatidyl Serine 200mg (Per Serving) 120 Vegetable Capsules Non-GMO Supports Memory & Brain Function

ML Naturals$14.75181 rev

3y ago

BulkSupplements.com Phosphatidylserine Capsules - Phosphatidylserine Supplement - Gluten Free 1 Capsule per Serving (60mg) 240 Capsules (Pack of 1)

BulkSupplements$24.2686 rev

3y ago

NOW Foods Supplements Soy-Free Phosphatidyl Serine (150mg) Brain Health* 60 Veg Capsules

NOW Foods$26.51392 rev

4y ago

What buyers say about phosphatidylserine

What buyers praise and complain about, mined from review topics.

What buyers love

Sleep Quality17%

“Helps with Sleep”

Quality-Overall13%

“the quality of its supporting ingredients”

Stress/Anxiety8%

“Stress reliever”

Focus Enhancement8%

“I think it is helping my memory”

Vitamin5%

“Great vitamin”

Value For Money5%

“Worth every penny”

Ingredients-Overall4%

“The pills seem to be made of good quality ingredients”

Efficiency4%

“Effective”

Advertised Vs Actual Product3%

“As advertised”

Ease Of Chewing/Swallowing3%

“not difficult for me to swallow”

What buyers complain about

Sleep Quality16%

“couldnt sleep again”

Functionality-Overall11%

“Didn't work for me”

Value For Money7%

“Waste of money”

Dosage6%

“Extremely under dosed”

Side Effects5%

“Side affects”

Stress/Anxiety5%

“My anxiety has been very bad”

Ingredients-Overall3%

“Active ingredient comes from freaking soy”

Advertised Vs Actual Product3%

“This product does not do as advertised”

Size-Overall3%

“The pills are a bit large”

Acid Regulator/Stomach Ache Relief2%

“can cause nausea”

Top return reasons

Sleep Quality21%

Functionality-Overall21%

Value For Money14%

Ease Of Chewing/Swallowing14%

Advertised Vs Actual Product14%

Quality-Overall7%

Temperature Retention7%

Common questions

Is phosphatidylserine profitable to sell on Amazon United States?: The niche generates $2.9M/yr across 21 tracked products. 0 of 1 products launched in the last 360 days are still selling. 90-day search growth is -3.8%. Flapen's verdict: Worth a look (67/100).
How competitive is the phosphatidylserine niche?: 14 brands and 30 sellers compete. The top 5 products take 60% of clicks and top 5 brands hold 63% of demand.
What do buyers complain about in phosphatidylserine?: Top complaints mined from reviews: Sleep Quality, Functionality-Overall, Value For Money. The return rate is 0.0%.
When does demand for phosphatidylserine peak?: Demand is steady year-round — the busiest month runs 1.4× the quietest.
What does it cost to enter the phosphatidylserine niche?: Listings span $14.75–$79.26; the average listing price is $32.51 (sweet spot $15–$100). The average incumbent carries 1,384 reviews — the moat a new listing must climb.