Is headache medicine profitable to sell on Amazon United States?

The niche generates $583K/yr across 9 tracked products. 1 of 1 products launched in the last 360 days are still selling. 90-day search growth is +0.2%. Flapen's verdict: Skip it (42/100).

How competitive is the headache medicine niche?

5 brands and 65 sellers compete. The top 5 products take 83% of clicks and top 5 brands hold 100% of demand.

What do buyers complain about in headache medicine?

Top complaints mined from reviews: Functionality-Overall, Smell, Dosage. The return rate is 0.0%.

When does demand for headache medicine peak?

Demand peaks in Jun–Jul–Aug; the busiest month runs 2.0× the quietest.

What does it cost to enter the headache medicine niche?

Listings span $4.89–$18.93; the average listing price is $12.46 (sweet spot $15–$100). The average incumbent carries 4,494 reviews — the moat a new listing must climb.

headache medicine

Skip it

Brand-locked demand (top 5 brands take 100% of clicks) — this niche doesn't clear our bar today.

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Conversion

Incredible17.9%

search→purchase rate — share of searches ending in a sale

Market size

Good$583K

$583K/yr · 261K searches

Avg price

Good$12.46

avg listing price — sweet spot $15–$100

Price range

Okay$4.89–$18.93

cheapest to priciest tracked listing — scored on the share inside $15–$100

Growth

Okay+0.2%

90-day search growth — must beat 0% to launch

Review moat

Bad4,493.56

avg incumbent reviews — the moat a new listing must climb

Quality gap

Bad4.7★

avg incumbent rating — lower means beatable quality

Competition

Bad83%

top-5 click share — a locked-up shelf

Brand share

Bad100%

top-5 brand share — brand-locked demand

According to Flapen's Amazon United States niche tracking, headache medicine is a $583K/yr Amazon United States market (261K searches/yr). The top 5 brands hold 100% of demand. Demand peaks in Jun–Jul–Aug. Verdict: Skip it — 42/100.

Data updated Jul 11, 2026 · scored weekly · How we score niches

headache medicine market data

Units sold / yr: 40K–50K; avg 5,000–6,000/product
Revenue / yr: $498K–$623K; units × avg price
Conversion rate: 17.9%
Avg BSR: #138
Page quality: 0%
Prime: 100%
Sponsored: 89%
Out of stock: 0.0%
Avg brand age: 86 months
Avg seller age: 153 days

Competition & brand share

The top 5 products capture 83% of clicks — a locked-up shelf that new listings rarely crack.

Brands

5 flat

Sellers

Top-5 brand share

100%

Top 20: 100%

Top-5 click share

83%

Top 20: 100%

Open market

Excedrin79%
GenCare9%
Amazon Basic Care5%
RIGHT REMEDIES4%
TIME-CAP LABS, INC.3%

Demand & seasonality

Weekly Amazon search volume, last 104 weeks — +0.2% search growth over the last 90 days.

Peak months: Jun, Jul, Aug · busiest ÷ quietest = 2.0×

Open Trend

Top headache medicine search terms

excedrin extra strength185K/yr -1.1%21.0% conv.
extra strength excedrin18K/yr -0.4%18.1% conv.
headache relief pills13K/yr +5.4%4.1% conv.
headache pills10K/yr +41.9%5.9% conv.
excedrin extra strength headache5K/yr +154.2%16.6% conv.
pastillas para dolor de cabeza7K/yr -5.6%0.5% conv.
pastillas para el dolor de cabeza6K/yr -13.7%0.5% conv.
head pain4K/yr +16.4%0.0% conv.
equate headache relief4K/yr +20.7%4.3% conv.
excedrin extra strength 300 count4K/yr -21.4%11.8% conv.

All search terms

Top headache medicine products on Amazon

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 9 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

Excedrin Extra Strength Pain Relief Caplets for Headache Relief Acetaminophen 250mg Aspirin 250mg Caffeine 65mg Pain Reliever 200 Count

Excedrin$18.934.8★8,774 rev

Excedrin Extra Strength Pain Relief Caplets Headache Relief 100 Count

Excedrin$12.194.8★2,771 rev

GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain Muscle Aches Back Pain & Body | Generic ExcedrEn Extra Strength

GenCare$13.884.7★7,776 rev

Excedrin Extra Strength Caplets for Headache Pain Relief Acetaminophen 250mg Aspirin 250mg Caffeine 65mg Pain Reliever 24 count

Excedrin$4.894.8★3,262 rev

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Excedrin$18.894.9★14,121 rev

Newest

by launch date

Excedrin Rapid Relief Caplets 500mg Acetaminophen Fast Pain Relief in 15 Minutes 160 Count

Excedrin$16.13117 rev

3mo ago

RIGHT REMEDIES Extra Strength Headache Relief with Acetaminophen Aspirin (NSAID) & Caffeine (300 caplets) Back & Body Pain Relief Compare to the Active Ingredients in Excedrin Extra Strength

RIGHT REMEDIES$10.59249 rev

1y ago

TIME-Cap Labs Extra Strength Acetaminophen 250mg with Aspirin 250mg & Caffeine 65mg Caplets - Pain Reliever/Fever Reducer for Headache Relief Muscle Aches & Body Pain (300 Count)

TIME-CAP LABS, INC.$10.131,639 rev

2y ago

Amazon Basic Care Extra Strength Headache Relief Geltabs Pain Reliever for Arthritis Menstrual Pain and Cramps 80 Count

Amazon Basic Care$6.521,733 rev

4y ago

GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain Muscle Aches Back Pain & Body | Generic ExcedrEn Extra Strength

GenCare$13.887,776 rev

6y ago

What buyers say about headache medicine

What buyers praise and complain about, mined from review topics.

What buyers love

Value For Money22%

“Great Value”

Quality-Overall20%

“Amazon delivers on this value of quality aspirin”

Efficiency14%

“Effective”

Advertised Vs Actual Product11%

“As Described”

Ease Of Chewing/Swallowing4%

“The caplets are easy to take”

Ingredients-Overall4%

“Exact same ingredients as Excedrin”

Strength2%

“Effective”

Ease Of Use2%

“The caplets are easy to take”

Dosage2%

“the bottle contains a large quantity which makes it convenient to keep on hand”

Side Effects2%

“I always keep a bottle of Excedrin on hand because it has honestly been a lifesaver when headaches hit”

What buyers complain about

Functionality-Overall20%

“is no longer effective”

Smell10%

“Horrible smell”

Dosage6%

“I had to stop taken ibuprofen”

Ease Of Chewing/Swallowing5%

“As soon as I feel one coming on I chew one up so that it goes through my stomach walls quickly”

Acid Regulator/Stomach Ache Relief4%

“can cause stomach upset”

Size-Overall3%

“Much larger than I've seen before”

Side Effects3%

“Excedrin CAUSED my migraines”

Pain Relief-Overall3%

“it simply didnt provide the relief I was hoping for”

Advertised Vs Actual Product2%

“Doesnt look right”

Taste-Overall2%

“Terrible Taste”

Common questions

Is headache medicine profitable to sell on Amazon United States?: The niche generates $583K/yr across 9 tracked products. 1 of 1 products launched in the last 360 days are still selling. 90-day search growth is +0.2%. Flapen's verdict: Skip it (42/100).
How competitive is the headache medicine niche?: 5 brands and 65 sellers compete. The top 5 products take 83% of clicks and top 5 brands hold 100% of demand.
What do buyers complain about in headache medicine?: Top complaints mined from reviews: Functionality-Overall, Smell, Dosage. The return rate is 0.0%.
When does demand for headache medicine peak?: Demand peaks in Jun–Jul–Aug; the busiest month runs 2.0× the quietest.
What does it cost to enter the headache medicine niche?: Listings span $4.89–$18.93; the average listing price is $12.46 (sweet spot $15–$100). The average incumbent carries 4,494 reviews — the moat a new listing must climb.