Is diphenhydramine profitable to sell on Amazon United States?

The niche generates $532K/yr across 15 tracked products. 1 of 2 products launched in the last 360 days are still selling. 90-day search growth is +0.3%. Flapen's verdict: Skip it (43/100).

How competitive is the diphenhydramine niche?

11 brands and 60 sellers compete. The top 5 products take 71% of clicks and top 5 brands hold 84% of demand.

What do buyers complain about in diphenhydramine?

Top complaints mined from reviews: Sleep Quality, Allergies, Functionality-Overall. The return rate is 0.0%.

When does demand for diphenhydramine peak?

Demand is steady year-round — the busiest month runs 1.3× the quietest.

What does it cost to enter the diphenhydramine niche?

Listings span $4.12–$10.33; the average listing price is $8.24 (sweet spot $15–$100). The average incumbent carries 15,030 reviews — the moat a new listing must climb.

diphenhydramine

Skip it

Prices mostly outside the sweet spot ($4.12–$10.33) — this niche doesn't clear our bar today.

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Conversion

Incredible12.1%

search→purchase rate — share of searches ending in a sale

Market size

Good$532K

$532K/yr · 533K searches

Brand share

Okay84%

top-5 brand share — brands hold most of the demand

Growth

Okay+0.3%

90-day search growth — must beat 0% to launch

Competition

Bad71%

top-5 click share — a locked-up shelf

Avg price

Bad$8.24

avg listing price — sweet spot $15–$100

Review moat

Bad15,029.8

avg incumbent reviews — the moat a new listing must climb

Quality gap

Bad4.7★

avg incumbent rating — lower means beatable quality

Price range

Bad$4.12–$10.33

cheapest to priciest tracked listing — scored on the share inside $15–$100

According to Flapen's Amazon United States niche tracking, diphenhydramine is a $532K/yr Amazon United States market (533K searches/yr). The top 5 brands hold 84% of demand. Verdict: Skip it — 43/100.

Data updated Jul 11, 2026 · scored weekly · How we score niches

diphenhydramine market data

Units sold / yr: 60K–80K; avg 4,000–5,000/product
Revenue / yr: $494K–$659K; units × avg price
Conversion rate: 12.1%
Avg BSR: #88
Page quality: 0%
Prime: 100%
Sponsored: 80%
Out of stock: 0.0%
Avg brand age: 78 months
Avg seller age: 150 days

Competition & brand share

The top 5 products capture 71% of clicks — a locked-up shelf that new listings rarely crack.

Brands

11 rising

Sellers

Top-5 brand share

84%

Top 20: 100%

Top-5 click share

71%

Top 20: 100%

Open market

11%

Amazon Basic Care51%
HEALTH LFE11%
HealthA2Z10%
Generic7%
TIME-CAP LABS, INC.5%
ValuMeds4%
Open — no brand owns it (5 brands, 11%)

Demand & seasonality

Weekly Amazon search volume, last 104 weeks — +0.3% search growth over the last 90 days.

No pronounced peak months · busiest ÷ quietest = 1.3×

Open Trend

Top diphenhydramine search terms

diphenhydramine249K/yr +0.7%10.6% conv.
diphenhydramine 25mg113K/yr +10.5%18.0% conv.
generic benadryl27K/yr +18.2%19.8% conv.
amazon basic care34K/yr -36.8%0.3% conv.
amazon health30K/yr -25.9%0.0% conv.
diphenhydramine hcl13K/yr +11.6%7.8% conv.
diphenhydramine hcl 25 mg8K/yr +79.0%14.1% conv.
benadryl generic7K/yr +28.0%19.2% conv.
amazon basics medicine10K/yr -10.2%0.5% conv.
difenhidramina8K/yr +30.1%4.4% conv.

All search terms

Top diphenhydramine products on Amazon

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 15 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies Mini-Tabs 100 Count

Amazon Basic Care$4.124.8★54,786 rev

Amazon Basic Care Complete Allergy Relief Diphenhydramine HCl 25 mg Easy to Swallow Mini-Tabs Relieves Sneezing Itchy Eyes Runny Nose Itchy Throat 400 Count

Amazon Basic Care$8.124.8★54,786 rev

HEALTH LFE Allergy Relief Medicine Diphenhydramine HCl Caplets 25 mg | Children and Adults | Relieves Sneezing Runny Nose Hay Fever Symptoms Itchy Eyes and Throat (Large 1000 Count)

HEALTH LFE$10.124.8★2,715 rev

MedPlus Allergy Relief Medicine Diphenhydramine HCl 25 mg 1000 Tablets Antihistamine Relief for Indoor & Outdoor Allergies Made in USA

Generic$10.334.8★1,330 rev

TIME-Cap Labs 650 Caplets Diphenhydramine HCl 25mg Allergy Relief Antihistamine for Adults Helps Relieve Sneezing Runny Nose Itchy Watery Eyes & Itchy Throat

TIME-CAP LABS, INC.$8.774.8★5,236 rev

Newest

by launch date

Berkley Jensen Allergy Relief Tablets 25mg Diphenhydramine HCI 600 Count

berkley jensen$8.00189 rev

5mo ago

GoodMeds Allergy Medicine Antihistamine Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes Runny Nose Sneezing (25 mg 600 Tablets)

GoodMeds$9.60534 rev

6mo ago

HEALTH LFE HealthLife Sleep Aid (Diphenhydramine HCl Caplets 25 mg Blue) 300 Count

HEALTH LFE$7.03483 rev

3y ago

MedPlus Allergy Relief Medicine Diphenhydramine HCl 25 mg 1000 Tablets Antihistamine Relief for Indoor & Outdoor Allergies Made in USA

Generic$10.331,330 rev

3y ago

HealthA2Z Allergy Relief | Diphenhydramine HCL 25mg | Antihistamine | Relief from Itchy Throat Sneezing Runny Noses | Indoor & Outdoors Allergies (200 Caplets (Pack of 1))

HealthA2Z$5.452,441 rev

4y ago

What buyers say about diphenhydramine

What buyers praise and complain about, mined from review topics.

What buyers love

Value For Money26%

“much less expensive”

Sleep Quality14%

“Helps me sleep”

Allergies13%

“Good for allergies”

Quality-Overall10%

“the tablets have been consistent in quality”

Efficiency9%

“Does work”

Advertised Vs Actual Product8%

“As advertised”

Dosage3%

“Perfect dosage”

Ease Of Chewing/Swallowing2%

“I'm really glad I got what I ordered, because, although a little bigger, they're much easier to swallow and there's no horrible taste like the Tablets have”

Ease Of Use1%

“Easy to use”

Sinus Relief1%

“Helps with sinus and allergy issues”

What buyers complain about

Sleep Quality20%

“Did not help me sleep”

Allergies15%

“having allergic reaction to something”

Functionality-Overall12%

“Doesnt work well”

Dosage6%

“This dosage is not easy to find locally”

Value For Money4%

“cheaper”

Strength3%

“Not as strong as needed”

Taste-Overall2%

“found them to have a strong chemical taste”

Side Effects2%

“It literally makes me nauseous”

Ingredients-Overall2%

“The bottle is a bit more barebones than Equate”

Size-Overall2%

“Very small”

Common questions

Is diphenhydramine profitable to sell on Amazon United States?: The niche generates $532K/yr across 15 tracked products. 1 of 2 products launched in the last 360 days are still selling. 90-day search growth is +0.3%. Flapen's verdict: Skip it (43/100).
How competitive is the diphenhydramine niche?: 11 brands and 60 sellers compete. The top 5 products take 71% of clicks and top 5 brands hold 84% of demand.
What do buyers complain about in diphenhydramine?: Top complaints mined from reviews: Sleep Quality, Allergies, Functionality-Overall. The return rate is 0.0%.
When does demand for diphenhydramine peak?: Demand is steady year-round — the busiest month runs 1.3× the quietest.
What does it cost to enter the diphenhydramine niche?: Listings span $4.12–$10.33; the average listing price is $8.24 (sweet spot $15–$100). The average incumbent carries 15,030 reviews — the moat a new listing must climb.