Is antidepressants profitable to sell on Amazon United States?

The niche generates $309K/yr across 14 tracked products. 90-day search growth is -3.6%. Flapen's verdict: Skip it (49/100).

How competitive is the antidepressants niche?

6 brands and 618 sellers compete. The top 5 products take 78% of clicks and top 5 brands hold 98% of demand.

What do buyers complain about in antidepressants?

Top complaints mined from reviews: Functionality-Overall, Stress/Anxiety, Side Effects. The return rate is 0.0%.

When does demand for antidepressants peak?

Demand peaks in Sep; the busiest month runs 3.5× the quietest.

What does it cost to enter the antidepressants niche?

Listings span $8.54–$41.83; the average listing price is $17.96 (sweet spot $15–$100). The average incumbent carries 5,983 reviews — the moat a new listing must climb.

antidepressants

Skip it

Brand-locked demand (top 5 brands take 98% of clicks) — this niche doesn't clear our bar today.

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Conversion

Great9.4%

search→purchase rate — share of searches ending in a sale

Avg price

Great$17.96

avg listing price — sweet spot $15–$100

Price range

Great$8.54–$41.83

cheapest to priciest tracked listing — scored on the share inside $15–$100

Quality gap

Good4.4★

avg incumbent rating — lower means beatable quality

Market size

Good$309K

$309K/yr · 183K searches

Review moat

Bad5,983.07

avg incumbent reviews — the moat a new listing must climb

Growth

Bad-3.6%

90-day search growth — must beat 0% to launch

Competition

Bad78%

top-5 click share — a locked-up shelf

Brand share

Bad98%

top-5 brand share — brand-locked demand

According to Flapen's Amazon United States niche tracking, antidepressants is a $309K/yr Amazon United States market (183K searches/yr). The top 5 brands hold 98% of demand. Demand peaks in Sep. Verdict: Skip it — 49/100.

Data updated Jul 10, 2026 · scored weekly · How we score niches

antidepressants market data

Units sold / yr: 15K–20K; avg 1,250–1,500/product
Revenue / yr: $269K–$359K; units × avg price
Conversion rate: 9.4%
Avg BSR: #142
Page quality: 0%
Prime: 100%
Sponsored: 100%
Out of stock: 0.0%
Avg brand age: 61 months
Avg seller age: 157 days

Competition & brand share

The top 5 products capture 78% of clicks — a locked-up shelf that new listings rarely crack.

Brands

6 falling

Sellers

618

Top-5 brand share

98%

Top 20: 100%

Top-5 click share

78%

Top 20: 100%

Open market

Boiron74%
LifeSeasons9%
Laki Naturals7%
OLLY5%
Futurebiotics3%
Happy Healthy Hippie2%
Open — no brand owns it (0%)

Demand & seasonality

Weekly Amazon search volume, last 104 weeks — -3.6% search growth over the last 90 days.

Peak months: Sep · busiest ÷ quietest = 3.5×

Open Trend

Top antidepressants search terms

stress calm34K/yr +0.8%14.0% conv.
antidepressants24K/yr -4.8%1.1% conv.
boiron stress calm17K/yr -12.1%17.2% conv.
anti depressant15K/yr -8.5%1.4% conv.
stress calm boiron10K/yr +20.2%19.1% conv.
flight anxiety essentials11K/yr -18.2%1.7% conv.
antidepressants for women11K/yr -3.4%1.1% conv.
clordiazepoxido cubano9K/yr -24.1%2.8% conv.
sedative6K/yr +49.3%0.7% conv.
homeopathic anxiety relief6K/yr +8.7%6.1% conv.

All search terms

Top antidepressants products on Amazon

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 14 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

Boiron StressCalm Tablets for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - 60 Count

Boiron$8.544.3★7,644 rev

Boiron StressCalm Tablets for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - 120 Count

Boiron$15.734.3★7,644 rev

Boiron StressCalm On The Go for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - 2 Count (160 Pellets)

Boiron$9.304.3★1,668 rev

Boiron StressCalm Tabs - 100 Count for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - Convenient Stress Calm Meltaway Tablets

Boiron$18.204.9★40 rev

Laki Naturals Fly Calm Patch (1 Count Pack of 8) - Relax Nerves Support Stress - Natural Ingredients to Support Airplane Stress - Calm Your Fear of Flying Naturally

Laki Naturals$15.544.0★552 rev

Newest

by launch date

Boiron StressCalm Tabs - 100 Count for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - Convenient Stress Calm Meltaway Tablets

Boiron$18.2040 rev

1y ago

Futurebiotics Ashwagandha Extra Strength Stress & Mood Support 100 Capsules

Futurebiotics$9.7513,430 rev

2y ago

Anxie-T Plus - Extra Strength Stress Relief Supplement - Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha Kava Kava GABA & L-Theanine - 60 Capsules

LifeSeasons$41.83774 rev

2y ago

Futurebiotics Chill Pill + Ashwagandha Rhodiola St. Johns Wort & L-Theanine - Non-GMO 120 Vegetarian Tablets

Futurebiotics$9.942,015 rev

2y ago

Laki Naturals Fly Calm Patch (1 Count Pack of 8) - Relax Nerves Support Stress - Natural Ingredients to Support Airplane Stress - Calm Your Fear of Flying Naturally

Laki Naturals$15.54552 rev

2y ago

What buyers say about antidepressants

What buyers praise and complain about, mined from review topics.

What buyers love

Stress/Anxiety23%

“Anxiety relief”

Quality-Overall9%

“Excellent product”

Sleep Quality8%

“Helps with sleep”

Efficiency8%

“worked well for my needs”

Soothing Effect5%

“Soothing”

Taste-Overall5%

“Great taste, help with mood boosting”

Side Effects4%

“Most of my symptoms are gone or significantly reduced”

Focus Enhancement3%

“helps you focus”

Value For Money3%

“Good product for the price”

Advertised Vs Actual Product3%

“Works as advertised”

What buyers complain about

Functionality-Overall17%

“Did not seem to be effective”

Stress/Anxiety13%

“DOES NOT HELP STRESS”

Side Effects8%

“Side effects were scary”

Taste-Overall7%

“Bad Aftertaste”

Sleep Quality6%

“I struggle with sleep”

Value For Money5%

“Waste of money”

Dosage3%

“The 5 pill dose is too much for me”

Ingredients-Overall2%

“Could be because my body isnt used to the ingredients”

Heart Health2%

“Caused heart arrhythmia”

Allergies2%

“He was becoming irritated”

Top return reasons

Functionality-Overall27%

Magnesium9%

Value For Money9%

Ingredients-Overall9%

Fever Relief9%

Dosage9%

Advertised Vs Actual Product9%

Vitamin9%

Moist/Dry9%

Common questions

Is antidepressants profitable to sell on Amazon United States?: The niche generates $309K/yr across 14 tracked products. 90-day search growth is -3.6%. Flapen's verdict: Skip it (49/100).
How competitive is the antidepressants niche?: 6 brands and 618 sellers compete. The top 5 products take 78% of clicks and top 5 brands hold 98% of demand.
What do buyers complain about in antidepressants?: Top complaints mined from reviews: Functionality-Overall, Stress/Anxiety, Side Effects. The return rate is 0.0%.
When does demand for antidepressants peak?: Demand peaks in Sep; the busiest month runs 3.5× the quietest.
What does it cost to enter the antidepressants niche?: Listings span $8.54–$41.83; the average listing price is $17.96 (sweet spot $15–$100). The average incumbent carries 5,983 reviews — the moat a new listing must climb.

antidepressants

antidepressants market data

Competition & brand share

Demand & seasonality

Top antidepressants search terms

Top antidepressants products on Amazon

Top sellers

Newest

Trending

What buyers say about antidepressants

What buyers love

What buyers complain about

Top return reasons

Common questions

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