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49

painkiller

Skip it

Brand-locked demand (top 5 brands take 98% of clicks) — this niche doesn't clear our bar today.

Market size 92Growth 28Conversion 100Competition 12Returns 100Price range 50Avg price 69Brand share 5Review moat 23Quality gap 13

Conversion

Incredible21.5%

search→purchase rate — share of searches ending in a sale

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Market size

Great$1.8M

$1.8M/yr · 594K searches

Avg price

Good$14.27

avg listing price — sweet spot $15–$100

Price range

Good$4.12–$25.79

cheapest to priciest tracked listing — scored on the share inside $15–$100

Growth

Okay+2.8%

90-day search growth — must beat 0% to launch

Review moat

Bad7,924.4

avg incumbent reviews — the moat a new listing must climb

Quality gap

Bad4.8★

avg incumbent rating — lower means beatable quality

Competition

Bad86%

top-5 click share — a locked-up shelf

Brand share

Bad98%

top-5 brand share — brand-locked demand

According to Flapen's Amazon United States niche tracking, painkiller is a $1.8M/yr Amazon United States market (594K searches/yr). The top 5 brands hold 98% of demand. Verdict: Skip it — 49/100.

Data updated Jul 11, 2026 · scored weekly · How we score niches

painkiller market data

Units sold / yr
125K–150K
avg 12,500–15,000/product
Revenue / yr
$1.8M–$2.1M
units × avg price
Conversion rate
21.5%
Avg BSR
#59
Page quality
0%
Prime
100%
Sponsored
90%
Out of stock
0.0%
Avg brand age
84 months
Avg seller age
160 days

Competition & brand share

The top 5 products capture 86% of clicks — a locked-up shelf that new listings rarely crack.

Brands

6 rising

Sellers

68

Top-5 brand share

98%

Top 20: 100%

Top-5 click share

86%

Top 20: 100%

Open market

0%

  • Advil69%
  • Amazon Basic Care13%
  • A+Health9%
  • Glenmark Therapeutics4%
  • Motrin2%
  • HealthA2Z2%

Demand & seasonality

Weekly Amazon search volume, last 104 weeks — +2.8% search growth over the last 90 days.
13K8KPrime Day '25SepDecMarJunAugNovMarMay

No pronounced peak months · busiest ÷ quietest = 1.2×

Open Trend

Top painkiller search terms

  • advil dual action283K/yr
  • dual action pain reliever111K/yr
  • dual action17K/yr
  • advil dual action back pain14K/yr
  • advil tylenol dual action14K/yr
  • dual action advil15K/yr
  • advil dual13K/yr
  • ibuprofen and acetaminophen combo12K/yr
  • advil dual action with acetaminophen and ibuprofen26K/yr
  • duel action pain relief9K/yr
All search terms

Top painkiller products on Amazon

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

0%10%$182K20%$365K30%$547K40%$729K1001K10K100K Reviews — right = deep review moat Market share (90d) ≈ est. sales
Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 10 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share
1
Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 216 Count

Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 216 Count

Advil$25.784.8★14,896 rev

2
Advil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count

Advil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count

Advil$17.244.8★8,316 rev

3
Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 72 Count

Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 72 Count

Advil$10.534.8★14,896 rev

4
Amazon Basic Care Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets Pain Reliever for Headache Backache Menstrual Pain Arthritis Pain Relief 216 Count

Amazon Basic Care Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets Pain Reliever for Headache Backache Menstrual Pain Arthritis Pain Relief 216 Count

Amazon Basic Care$15.204.8★811 rev

5
A+Health Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125mg Pain Reliever Caplets 216 Count

A+Health Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125mg Pain Reliever Caplets 216 Count

A+Health$11.344.8★2,303 rev

Newest

by launch date
HealthA2Z Dual Action Pain Relief | Acetaminophen 250mg & Ibuprofen (NSAID) 125mg | Contains Two Medicines | Relief from Headache Fever & Backache (150 Caplets)

HealthA2Z Dual Action Pain Relief | Acetaminophen 250mg & Ibuprofen (NSAID) 125mg | Contains Two Medicines | Relief from Headache Fever & Backache (150 Caplets)

HealthA2Z$9.661,026 rev

2y ago
Dual Action Acetaminophen 250mg and Ibuprofen 125mg Caplets Up to 8h of Pain Relief for Minor Aches and Pain Headaches Toothache Backache Menstrual Cramps Minor Arthritis Pain 216 Count

Dual Action Acetaminophen 250mg and Ibuprofen 125mg Caplets Up to 8h of Pain Relief for Minor Aches and Pain Headaches Toothache Backache Menstrual Cramps Minor Arthritis Pain 216 Count

Glenmark Therapeutics$9.771,253 rev

2y ago
Amazon Basic Care Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets Pain Reliever for Headache Backache Menstrual Pain Arthritis Pain Relief 216 Count

Amazon Basic Care Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets Pain Reliever for Headache Backache Menstrual Pain Arthritis Pain Relief 216 Count

Amazon Basic Care$15.20811 rev

2y ago
Motrin Dual Action with Tylenol Ibuprofen & Acetaminophen Fast-Acting Long Lasting Pain Reliever for Minor Aches & Pains Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg 120 ct

Motrin Dual Action with Tylenol Ibuprofen & Acetaminophen Fast-Acting Long Lasting Pain Reliever for Minor Aches & Pains Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg 120 ct

Motrin$13.275,951 rev

3y ago
Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 216 Count

Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 216 Count

Advil$25.7814,896 rev

3y ago

Trending

90-day click momentum
Amazon Basic Care Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets Pain Reliever for Headache Backache Menstrual Pain Arthritis Pain Relief 216 Count

Amazon Basic Care Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets Pain Reliever for Headache Backache Menstrual Pain Arthritis Pain Relief 216 Count

Amazon Basic Care$15.204.8★

▲ 59%
Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 2 Count x 50

Advil Dual Action Coated Caplets with Acetaminophen 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief - 2 Count x 50

Advil$25.794.8★

▲ 19%
Advil Dual Action Coated Caplets with Acetaminophen 125mg Ibuprofen and 250mg Acetaminophen Per Caplet for 8 Hour Pain Relief - 18 Count

Advil Dual Action Coated Caplets with Acetaminophen 125mg Ibuprofen and 250mg Acetaminophen Per Caplet for 8 Hour Pain Relief - 18 Count

Advil$4.124.8★

▲ 19%
Dual Action Acetaminophen 250mg and Ibuprofen 125mg Caplets Up to 8h of Pain Relief for Minor Aches and Pain Headaches Toothache Backache Menstrual Cramps Minor Arthritis Pain 216 Count

Dual Action Acetaminophen 250mg and Ibuprofen 125mg Caplets Up to 8h of Pain Relief for Minor Aches and Pain Headaches Toothache Backache Menstrual Cramps Minor Arthritis Pain 216 Count

Glenmark Therapeutics$9.774.8★

▲ 17%
Advil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count

Advil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count

Advil$17.244.8★

— 3%

What buyers say about painkiller

What buyers praise and complain about, mined from review topics.

What buyers love

Value For Money23%

“Good Value for the Money”

Efficiency16%

“provides consistent results”

Advertised Vs Actual Product10%

“As advertised”

Quality-Overall8%

“Just as good as name brand”

Joint Pain7%

“Helps knees and shoulders”

Muscle Pain Relief5%

“Works good for minor aches and pain”

Dosage4%

“Safe doses”

Ease Of Use3%

“Very convenient”

Ease Of Chewing/Swallowing3%

“Easy on the stomach, works quick, packed well on time”

Side Effects2%

“No side effects”

What buyers complain about

Pain Relief-Overall18%

“Ive had pain in my right wrist for years and nothing helped,”

Dosage12%

“I feel like this is odd dosage amounts”

Value For Money6%

“A bit costly”

Taste-Overall5%

“No taste”

Advertised Vs Actual Product5%

“This is misleading advertising”

Quality-Overall5%

“Garbage”

Artificial Sweeteners4%

“Artificial sweetener ingredients”

Strength3%

“Not strong enough”

Allergies3%

“Those made me itchy or nauseous”

Sleep Quality3%

“But not helping you sleep”

Common questions

Is painkiller profitable to sell on Amazon United States?
The niche generates $1.8M/yr across 10 tracked products. 90-day search growth is +2.8%. Flapen's verdict: Skip it (49/100).
How competitive is the painkiller niche?
6 brands and 68 sellers compete. The top 5 products take 86% of clicks and top 5 brands hold 98% of demand.
What do buyers complain about in painkiller?
Top complaints mined from reviews: Pain Relief-Overall, Dosage, Value For Money. The return rate is 0.0%.
When does demand for painkiller peak?
Demand is steady year-round — the busiest month runs 1.2× the quietest.
What does it cost to enter the painkiller niche?
Listings span $4.12–$25.79; the average listing price is $14.27 (sweet spot $15–$100). The average incumbent carries 7,924 reviews — the moat a new listing must climb.