Mthfr Supplement
Worth a lookShows low returns (0.0%), but brand-locked demand (top 5 brands take 100% of clicks) keeps it on the watch list.
Returns
Incredible0.0%return rate — above 5% kills the launch gate
Conversion
Great12.0%search→purchase rate — share of searches ending in a sale
Avg price
Incredible$29.78avg listing price — sweet spot $15–$100
Price range
Incredible$14.99–$67.44cheapest to priciest tracked listing — scored on the share inside $15–$100
Market size
Great$1.8M$1.8M/yr · 506K searches
Growth
Okay+15.4%90-day search growth — must beat 0% to launch
Review moat
Okay3,319.1avg incumbent reviews — the moat a new listing must climb
Quality gap
Bad4.6★avg incumbent rating — lower means beatable quality
Competition
Bad84%top-5 click share — a locked-up shelf
Brand share
Bad100%top-5 brand share — brand-locked demand
Is mthfr supplement profitable on Amazon?
According to Flapen's Amazon United States niche tracking, mthfr supplement is a $1.8M/yr Amazon United States market (506K searches/yr). The top 5 brands hold 100% of demand. Verdict: Worth a look — 55/100.
Data updated Jul 28, 2026 · scored weekly · How we score niches
mthfr supplement market size & sales
Units sold, revenue, conversion and listing quality across the tracked shelf.- Units sold / yr
- 50K–60K
- avg 4,000–5,000/product
- Revenue / yr
- $1.5M–$1.8M
- units × avg price
- Conversion rate
- 12.0%
- Avg BSR
- #2,562
- Page quality
- 0%
- Prime
- 90%
- Sponsored
- 100%
- Out of stock
- 0.0%
- Avg brand age
- 60 months
- Avg seller age
- 157 days
Competition: brands, sellers & click share
The top 5 products capture 84% of clicks — a locked-up shelf that new listings rarely crack.Brands
4 flat
Sellers
7
Top-5 brand share
100%
Top 20: 100%
Top-5 click share
84%
Top 20: 100%
Open market
0%
- Triquetra Health73%
- THORNE22%
- C&D Jewelry3%
- Micro Ingredients3%
mthfr supplement demand & seasonality
Weekly Amazon search volume, last 104 weeks — +15.4% search growth over the last 90 days.No pronounced peak months · busiest ÷ quietest = 1.3×
Top mthfr supplement search terms shoppers use
The exact queries shoppers type, with yearly volume, growth and conversion.- mthfr supplement94K/yr
- 5-mthf84K/yr
- triquetra85K/yr
- 5 mthf58K/yr
- 5mthf39K/yr
- mthfr36K/yr
- mthf13K/yr
- thorne methylfolate14K/yr
- mtfr supplement8K/yr
- 5 methylfolate supplement7K/yr
Top mthfr supplement products & what they sell for
Every tracked product — its share of the shelf, its review moat, and what it sells for.Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
All 10 tracked products in this niche — three views at once, no toggling.
Top sellers
by 90-day click share
L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$21.674.6★9,407 rev
THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health Fetal Development Nerve Health Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg
THORNE$23.884.7★4,081 rev
L Methyl Folate 15mg Plus Methyl B12 Cofactor Organic Berry Flavor High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms Vitamin B9 & B12 (1oz)
Triquetra Health$21.874.5★5,924 rev
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) Metabolically Active 5-MTHF Form Organic Berry Flavor Liquid Sublingual Form Mood Cognition Methylation Pregnancy (1oz)
Triquetra Health$21.844.6★4,077 rev
Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz
Triquetra Health$19.204.5★2,493 rev
Newest
by launch date
Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil
Micro Ingredients$28.48289 rev
Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz
Triquetra Health$19.202,493 rev
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834,077 rev
L Methyl Folate 15mg Plus Methyl B12 Cofactor Organic Berry Flavor High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms Vitamin B9 & B12 (1oz)
Triquetra Health$21.875,924 rev
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) Metabolically Active 5-MTHF Form Organic Berry Flavor Liquid Sublingual Form Mood Cognition Methylation Pregnancy (1oz)
Triquetra Health$21.844,077 rev
Trending
90-day click momentum
Irish Ring Claddagh Rings for Women. (Size 7) Stainless Steel - Lovers Heart Celtic Rings for Women with Triquetra Ring Jewelry Design - Irish Gifts (7)
C&D Jewelry$14.994.4★
Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil
Micro Ingredients$28.484.8★
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834.6★
L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$21.674.6★
Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz
Triquetra Health$19.204.5★
What reviews say buyers love and hate about mthfr supplement
What buyers praise and complain about, mined from review topics.What buyers love
“Quality and ease of use”
“Doesnt taste bad”
“Great vitamin”
“feel like it improves my mood”
“Lots of Energy”
“Effective”
“Just as advertised”
“Great value”
“Easy to use”
“Great product when you get the right dosage”
What buyers complain about
“Doesn't do anything”
“had some strange side effects”
“Unless you've been specifically instructed by a doctor to take this high of a dosage”
“It tastes terrible”
“Way too much Vitamin B9 and B12”
“The price is a little high”
“Its not as good as they make it seem”
“I also couldnt sleep”
“Allergic”
“Seemed to cause anxiety”
Top return reasons
Common mthfr supplement questions
- Is mthfr supplement profitable to sell on Amazon United States?
- The niche generates $1.8M/yr across 10 tracked products. 90-day search growth is +15.4%. Flapen's verdict: Worth a look (55/100).
- How competitive is the mthfr supplement niche?
- 4 brands and 7 sellers compete. The top 5 products take 84% of clicks and top 5 brands hold 100% of demand.
- What do buyers complain about in mthfr supplement?
- Top complaints mined from reviews: Functionality-Overall, Side Effects, Dosage. The return rate is 0.0%.
- When does demand for mthfr supplement peak?
- Demand is steady year-round — the busiest month runs 1.3× the quietest.
- What does it cost to enter the mthfr supplement niche?
- Listings span $14.99–$67.44; the average listing price is $29.78 (sweet spot $15–$100). The average incumbent carries 3,319 reviews — the moat a new listing must climb.