Methylfolate
Launch itA $5.2M/yr market growing +19.9% this quarter with returns at 0.0% — clears our launch bar.
Returns
Incredible0.0%return rate — above 5% kills the launch gate
Market size
Incredible$5.2M$5.2M/yr · 1.9M searches
Conversion
Incredible13.5%search→purchase rate — share of searches ending in a sale
Avg price
Great$20.11avg listing price — sweet spot $15–$100
Price range
Great$12.00–$29.92cheapest to priciest tracked listing — scored on the share inside $15–$100
Growth
Okay+19.9%90-day search growth — must beat 0% to launch
Review moat
Okay3,668.38avg incumbent reviews — the moat a new listing must climb
Quality gap
Bad4.6★avg incumbent rating — lower means beatable quality
Competition
Bad74%top-5 click share — a locked-up shelf
Brand share
Bad95%top-5 brand share — brand-locked demand
Is methylfolate profitable on Amazon?
According to Flapen's Amazon United States niche tracking, methylfolate is a $5.2M/yr Amazon United States market (1.9M searches/yr). The top 5 brands hold 95% of demand. Verdict: Launch it — 58/100.
Data updated Jul 28, 2026 · scored weekly · How we score niches
methylfolate market size & sales
Units sold, revenue, conversion and listing quality across the tracked shelf.- Units sold / yr
- 250K–300K
- avg 15,000–20,000/product
- Revenue / yr
- $5.0M–$6.0M
- units × avg price
- Conversion rate
- 13.5%
- Avg BSR
- #10
- Page quality
- 0%
- Prime
- 100%
- Sponsored
- 92%
- Out of stock
- 0.0%
- Avg brand age
- 61 months
- Avg seller age
- 141 days
Competition: brands, sellers & click share
The top 5 products capture 74% of clicks — a locked-up shelf that new listings rarely crack.Brands
7 falling
Sellers
20
Top-5 brand share
95%
Top 20: 100%
Top-5 click share
74%
Top 20: 100%
Open market
3%
- Triquetra Health71%
- Nutricost10%
- THORNE6%
- NOW Foods5%
- Carlyle3%
- Micro Ingredients3%
- Open — no brand owns it (1 brand, 3%)
methylfolate demand & seasonality
Weekly Amazon search volume, last 104 weeks — +19.9% search growth over the last 90 days.No pronounced peak months · busiest ÷ quietest = 1.3×
Top methylfolate search terms shoppers use
The exact queries shoppers type, with yearly volume, growth and conversion.- methylfolate630K/yr
- l methylfolate194K/yr
- l-methylfolate150K/yr
- triquetra l-methylfolate 5-mthf101K/yr
- mthfr supplement94K/yr
- methyl folate105K/yr
- 5-mthf84K/yr
- l methylfolate 15mg77K/yr
- methylated folate89K/yr
- 5 mthf58K/yr
Top methylfolate products & what they sell for
Every tracked product — its share of the shelf, its review moat, and what it sells for.Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
All 13 tracked products in this niche — three views at once, no toggling.
Top sellers
by 90-day click share
L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$21.674.6★9,407 rev
L Methyl Folate 15mg Plus Methyl B12 Cofactor Organic Berry Flavor High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms Vitamin B9 & B12 (1oz)
Triquetra Health$21.874.5★5,924 rev
Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz
Triquetra Health$19.204.5★2,493 rev
Nutricost Methylfolate 1000mcg 120 Vegetarian Capsules Gluten Free
Nutricost$12.804.8★1,763 rev
THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health Fetal Development Nerve Health Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg
THORNE$23.884.7★4,081 rev
Newest
by launch date
Vocks L Methylfolate 15mg | 5-MTHF + Methyl B12 | High Potency Methylfolate Supplement | Active Methylated Folate Vitamin B9 | MTHFR Supplement| Folate Supplement for Women & Men | 90 Capsules
Vocks$12.4597 rev
Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil
Micro Ingredients$28.48289 rev
Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz
Triquetra Health$19.202,493 rev
L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood Homocysteine Methylation Cognition (60 Capsules)
Triquetra Health$19.80754 rev
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834,077 rev
Trending
90-day click momentumVocks L Methylfolate 15mg | 5-MTHF + Methyl B12 | High Potency Methylfolate Supplement | Active Methylated Folate Vitamin B9 | MTHFR Supplement| Folate Supplement for Women & Men | 90 Capsules
Vocks$12.454.5★
Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil
Micro Ingredients$28.484.8★
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834.6★
L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$21.674.6★
L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood Homocysteine Methylation Cognition (60 Capsules)
Triquetra Health$19.804.6★
What reviews say buyers love and hate about methylfolate
What buyers praise and complain about, mined from review topics.What buyers love
“Quality and ease of use”
“Great vitamin option”
“Doesnt taste bad”
“helps with focus”
“Lots of Energy”
“Effective”
“Just as advertised”
“Good value”
“Easy to use”
“Easy dosages”
What buyers complain about
“Doesn't do anything”
“had some strange side effects”
“High dosage”
“It tastes terrible”
“Way too much Vitamin B9 and B12”
“Its not as good as they make it seem”
“A bit expensive”
“although I feel awesome I can not sleep”
“Allergic”
“Seemed to cause anxiety”
Top return reasons
Common methylfolate questions
- Is methylfolate profitable to sell on Amazon United States?
- The niche generates $5.2M/yr across 13 tracked products. 1 of 1 products launched in the last 360 days are still selling. 90-day search growth is +19.9%. Flapen's verdict: Launch it (58/100).
- How competitive is the methylfolate niche?
- 7 brands and 20 sellers compete. The top 5 products take 74% of clicks and top 5 brands hold 95% of demand.
- What do buyers complain about in methylfolate?
- Top complaints mined from reviews: Functionality-Overall, Side Effects, Dosage. The return rate is 0.0%.
- When does demand for methylfolate peak?
- Demand is steady year-round — the busiest month runs 1.3× the quietest.
- What does it cost to enter the methylfolate niche?
- Listings span $12.00–$29.92; the average listing price is $20.11 (sweet spot $15–$100). The average incumbent carries 3,668 reviews — the moat a new listing must climb.