Methylation
MaybeAn estimated 0.0% of orders come back. But the top 5 brands take 95% of clicks, so Methylation is a Maybe.
- Flapen Score
- 51 / 100Top 40% of 14,768 Health & Household niches · +2 vs the category median of 4951
- Market size
- $344K/yr50K searches / yr
- 90-day growth
- -20.6%search demand this quarter
- Competition
- 72%top-5 click share · 7 brands · 9 sellers
Flapen Score
Methylation against its category
The dotted line is the Health & Household average. Past it, Methylation is stronger. Inside it, weaker.
Market
The Methylation market on Amazon at a glance
Shoppers on Amazon United States searched for Methylation 50K times last year and spent an estimated $344K. The top 5 brands take 95% of clicks. Flapen scores it 51 out of 100, a Maybe.
01 · Demand
An estimated 15.3% of those searches ended in a purchase.
Shoppers searched for this 50K times in the last 12 months. That counts every search on Amazon United States for this niche's terms. An estimated 15.3% of those searches ended in a purchase. Searches in the last 90 days moved -20.6% against the 90 days before. Searches, conversion and average price together put the market at an estimated $344K a year.
- Searches, last 12 months
- 50K
- Growth, 90 days vs prior 90
- -20.6%
- Conversion, latest week
- 15.3%
- Market size, estimated
- $344Ka year
- Top search term
- amy myers10K searches a year
02 · Price
A sale here is worth $45.24.
Listings sell for $45.24 on average, from $21.67 to $61.16. Amazon reports units sold in ranges. This niche sold 5K to 6K a year. The average listing sells 100 to 250 of them. At $45.24 that is $5K to $11K a year per listing.
- Average price
- $45.24inside the $15 to $100 sweet spot
- Price range
- $21.67–$61.16
- Amazon United States median price
- $24.38across 115,062 niches
- Units sold a year
- 5K–6K
- Units per listing a year
- 100–250
- Revenue per listing a year
- $5K–$11K
- Returns
- 0.0%of orders · Amazon United States median 2.1%
03 · Entry bar
The bar here is ads.
100% of listings pay for placement with sponsored ads. 100% ship with Prime. On an average day, 0.0% of listings are out of stock. The average listing ranks #527 within Vitamin B. It carries 1,253 reviews at 4.51 stars, so a new listing needs social proof before a better product.
- Sponsored listings
- 100%
- Prime listings
- 100%
- Out of stock, average day
- 0.0%
- Average rank
- #527in Vitamin B
- Average rating
- 4.51 starsAmazon United States average 4.42 stars
- Average reviews
- 1,253per listing
- Listings tracked
- 17
04 · Newcomers
Brands here are established.
The brands on the shelf have sold for 77 months on average, so the names here are established.
- Launched, last 12 months
- 0
- Successful launches
- 0Amazon's first-year sales bar
- Average brand age
- 77 months
Products
Top Methylation products & what they sell for
The products selling here, as shoppers see them on Amazon. Shelf share and sales are our estimates.
Prices and ratings read from Amazon on Jul 28, 2026. The live listing can differ.
Top sellers
by estimated 90-day click share
Metagenics MethylCare - Folate L-5-MTHF Methyl B12 B6 NAC & Betaine HCl - Supports Homocysteine Metabolism Methylation & Heart Health - Non-GMO & Gluten-Free - 120 Capsules
- Price
- $44.23
- Rating
- 4.8/5
- Reviews
- 325
- Age
- 8y ago

Pure Encapsulations MethylAssist 90s - B Vitamin Complex - Methylation Support* - Heart Health & Brain Health - Non-GMO & Gluten Free - 90 Capsules
- Price
- $61.16
- Rating
- 4.6/5
- Reviews
- 480
- Age
- 12y ago

L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
- Price
- $21.67
- Rating
- 4.6/5
- Reviews
- 9,407
- Age
- 5y ago

Amy Myers MD Leaky Gut Revive - Gluten-Free & Non-Dairy - Botanical Blend for Healthy Gut Support - GI Health Support with Prebiotic Fiber Slippery Elm Bark & Marshmallow Root - 6.3 oz (30 Servings)
- Price
- $47.67
- Rating
- 4.2/5
- Reviews
- 1,286
- Age
- 8y ago

THORNE - Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2 B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten Dairy & Soy-Free - 30 Servings
- Price
- $60.66
- Rating
- 4.7/5
- Reviews
- 1,776
- Age
- 15y ago
Trending
estimated 90-day click momentum
Amy Myers MD Collagen Protein Powder - Type 1 & 3 Collagen - Bovine Collagen to Support Healthy Hair Skin & Nails - Gluten-Free Dairy-Free & Non-Soy - 16.08 oz (38 Servings)
- Price
- $47.94
- Rating
- 4.5/5
- Reviews
- 620
- Age
- 8y ago

Amy Myers MD Leaky Gut Revive - Gluten-Free & Non-Dairy - Botanical Blend for Healthy Gut Support - GI Health Support with Prebiotic Fiber Slippery Elm Bark & Marshmallow Root - 6.3 oz (30 Servings)
- Price
- $47.67
- Rating
- 4.2/5
- Reviews
- 1,286
- Age
- 8y ago

Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin B6 B12 Folate L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)
- Price
- $33.99
- Rating
- 4.8/5
- Reviews
- 949
- Age
- 5y ago

Amy Myers MD The Myers Way Multivitamin - Supports Healthy Immune Thyroid & Adrenal Function - Gluten-Free Non-Dairy & Iron Free Healthcare Supplement
- Price
- $49.16
- Rating
- 4.5/5
- Reviews
- 459
- Age
- 9y ago

Amy Myers MD Paleo Protein Powder - with Collagen Peptides for Gut Health - Supports Hair Skin & Nails - Non-GMO Gluten-Free Non-Dairy & More - Vanilla Bean - 19.54 oz (20 Servings)
- Price
- $45.25
- Rating
- 4.1/5
- Reviews
- 29
- Age
- 1y ago
Newest
by launch date
Amy Myers MD Paleo Protein Powder - with Collagen Peptides for Gut Health - Supports Hair Skin & Nails - Non-GMO Gluten-Free Non-Dairy & More - Vanilla Bean - 19.54 oz (20 Servings)
- Price
- $45.25
- Rating
- 4.1/5
- Reviews
- 29
- Age
- 1y ago

Amy Myers MD Paleo Protein Powder - Double Chocolate 20 Servings - Collagen-Based Gut Function Support - Gluten-Free & Non-Dairy Protein Supplement
- Price
- $45.05
- Rating
- 4.9/5
- Reviews
- 27
- Age
- 1y ago

Amy Myers MD Methylation Support - MTHFR Supplement - Supports Adrenal Function Gut & Liver Health - Contains Folate Vitamin B12 B6 & B2 - Non-GMO & Gluten-Free - 60 Capsules (30 Servings)
- Price
- $32.89
- Rating
- 4.3/5
- Reviews
- 39
- Age
- 2y ago

Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin B6 B12 Folate L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)
- Price
- $33.99
- Rating
- 4.8/5
- Reviews
- 949
- Age
- 5y ago

L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
- Price
- $21.67
- Rating
- 4.6/5
- Reviews
- 9,407
- Age
- 5y ago
Competition
Competition: brands, sellers & click share
The top 5 products take an estimated 72% of clicks. A locked shelf that new listings rarely crack.
Brands
7 falling
Sellers
9
Est. top-5 brand share
95%
Top 20: 100%
Est. top-5 click share
72%
Top 20: 100%
Open market
2%
- Metagenics28%
- Pure Encapsulations28%
- Amy Myers MD27%
- THORNE6%
- Triquetra Health6%
- Designs for Health3%
- Open — no brand owns it (1 brand, 2%)
Demand
Methylation search demand
Weekly searches over the year, seasonality beneath. Pick a range.
Peak months: Mar · busiest ÷ quietest = 4.4× · 8 of 12 months tracked
Search terms
Top Methylation search terms shoppers use
The exact words shoppers type, with estimated yearly volume, growth, and conversion.
- amy myers10K/yr
- methylation8K/yr
- methylation support11K/yr
- metagenics methylcare3K/yr
- amy meyers3K/yr
- methyl assist2K/yr
- methyl assist pure encapsulations2K/yr
- methylcare metagenics3K/yr
- amy myers md3K/yr
- pure encapsulations methylassist1K/yr
Reviews and returns
What reviews say buyers love and hate about Methylation
We read the reviews and the return reasons for every product selling here.
“Dosage is too high”
Every topic
Every topic buyers talk about, one row each.
Red shows the share of negative reviews and green the share of positive reviews, biggest topic first. Open a row to read what they wrote.
22 topics
Keep looking
Related niches
Niches in the same category that score near this one. Research these next.
Best Flapen score
The highest-scoring niches we track right now, across every category.
FAQ
Common Methylation questions
Answered from the same tracked data.
Figures on this page are estimates modeled from public Amazon pages and third-party keyword data. Amazon does not supply them, and no connected seller's data is used. How we handle Amazon data









