Is methylation profitable to sell on Amazon United States?

The niche generates $344K/yr across 17 tracked products. 90-day search growth is -20.6%. Flapen's verdict: Worth a look (51/100).

How competitive is the methylation niche?

7 brands and 9 sellers compete. The top 5 products take 72% of clicks and top 5 brands hold 95% of demand.

What do buyers complain about in methylation?

Top complaints mined from reviews: Dosage, Vitamin, Functionality-Overall. The return rate is 0.0%.

What does it cost to enter the methylation niche?

Listings span $21.67–$61.16; the average listing price is $45.24 (sweet spot $15–$100). The average incumbent carries 1,253 reviews — the moat a new listing must climb.

Methylation

Worth a look

Shows low returns (0.0%), but brand-locked demand (top 5 brands take 95% of clicks) keeps it on the watch list.

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Conversion

Incredible15.3%

search→purchase rate — share of searches ending in a sale

Avg price

Incredible$45.24

avg listing price — sweet spot $15–$100

Price range

Incredible$21.67–$61.16

cheapest to priciest tracked listing — scored on the share inside $15–$100

Review moat

Good1,253.12

avg incumbent reviews — the moat a new listing must climb

Market size

Good$344K

$344K/yr · 50K searches

Quality gap

Okay4.5★

avg incumbent rating — lower means beatable quality

Competition

Bad72%

top-5 click share — a locked-up shelf

Growth

Bad-20.6%

90-day search growth — must beat 0% to launch

Brand share

Bad95%

top-5 brand share — brand-locked demand

Signals Low Review Barrier

Is methylation profitable on Amazon?

According to Flapen's Amazon United States niche tracking, methylation is a $344K/yr Amazon United States market (50K searches/yr). The top 5 brands hold 95% of demand. Verdict: Worth a look — 51/100.

Data updated Jul 28, 2026 · scored weekly · How we score niches

methylation market size & sales

Units sold, revenue, conversion and listing quality across the tracked shelf.

Units sold / yr: 5K–6K; avg 100–250/product
Revenue / yr: $226K–$271K; units × avg price
Conversion rate: 15.3%
Avg BSR: #527
Page quality: 0%
Prime: 100%
Sponsored: 100%
Out of stock: 0.0%
Avg brand age: 77 months
Avg seller age: 164 days

Competition: brands, sellers & click share

The top 5 products capture 72% of clicks — a locked-up shelf that new listings rarely crack.

Brands

7 falling

Sellers

Top-5 brand share

95%

Top 20: 100%

Top-5 click share

72%

Top 20: 100%

Open market

Metagenics28%
Pure Encapsulations28%
Amy Myers MD27%
THORNE6%
Triquetra Health6%
Designs for Health3%
Open — no brand owns it (1 brand, 2%)

methylation demand & seasonality

Weekly Amazon search volume, last 34 weeks — -20.6% search growth over the last 90 days.

Open Trend

Top methylation search terms shoppers use

The exact queries shoppers type, with yearly volume, growth and conversion.

amy myers10K/yr -15.0%4.0% conv.
methylation8K/yr +0.4%2.2% conv.
methylation support11K/yr -53.5%5.3% conv.
metagenics methylcare3K/yr +11.2%29.6% conv.
amy meyers3K/yr +0.1%6.7% conv.
methyl assist2K/yr +16.8%15.0% conv.
methyl assist pure encapsulations2K/yr -3.9%24.1% conv.
methylcare metagenics3K/yr -15.0%29.1% conv.
amy myers md3K/yr -25.1%4.3% conv.
pure encapsulations methylassist1K/yr -15.8%18.5% conv.

All search terms

Top methylation products & what they sell for

Every tracked product — its share of the shelf, its review moat, and what it sells for.

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 17 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

Metagenics MethylCare - Folate L-5-MTHF Methyl B12 B6 NAC & Betaine HCl - Supports Homocysteine Metabolism Methylation & Heart Health - Non-GMO & Gluten-Free - 120 Capsules

Metagenics$44.234.8★325 rev

Pure Encapsulations MethylAssist 90s - B Vitamin Complex - Methylation Support* - Heart Health & Brain Health - Non-GMO & Gluten Free - 90 Capsules

Pure Encapsulations$61.164.6★480 rev

L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)

Triquetra Health$21.674.6★9,407 rev

Amy Myers MD Leaky Gut Revive - Gluten-Free & Non-Dairy - Botanical Blend for Healthy Gut Support - GI Health Support with Prebiotic Fiber Slippery Elm Bark & Marshmallow Root - 6.3 oz (30 Servings)

Amy Myers MD$47.674.2★1,286 rev

THORNE - Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2 B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten Dairy & Soy-Free - 30 Servings

THORNE$60.664.7★1,776 rev

Newest

by launch date

Amy Myers MD Paleo Protein Powder - with Collagen Peptides for Gut Health - Supports Hair Skin & Nails - Non-GMO Gluten-Free Non-Dairy & More - Vanilla Bean - 19.54 oz (20 Servings)

Amy Myers MD$45.2529 rev

1y ago

Amy Myers MD Paleo Protein Powder - Double Chocolate 20 Servings - Collagen-Based Gut Function Support - Gluten-Free & Non-Dairy Protein Supplement

Amy Myers MD$45.0527 rev

1y ago

Amy Myers MD Methylation Support - MTHFR Supplement - Supports Adrenal Function Gut & Liver Health - Contains Folate Vitamin B12 B6 & B2 - Non-GMO & Gluten-Free - 60 Capsules (30 Servings)

Amy Myers MD$32.8939 rev

2y ago

Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin B6 B12 Folate L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)

Designs for Health$33.99949 rev

5y ago

L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)

Triquetra Health$21.679,407 rev

5y ago

What reviews say buyers love and hate about methylation

What buyers praise and complain about, mined from review topics.

What buyers love

Quality-Overall19%

“Good quality suppliment”

Vitamin14%

“Definitely a very potent vitamin”

Advertised Vs Actual Product8%

“Just as advertised”

Value For Money6%

“Great product for a reasonable price”

Focus Enhancement6%

“improves mood naturally”

Efficiency6%

“Works well”

Energy Level5%

“Gave me lots of energy”

Nutritional Content2%

“I've been very happy with this supplement”

Ease Of Use2%

“Ease”

Taste-Overall2%

“The drops have a potent taste”

What buyers complain about

Dosage11%

“Dosage is too high”

Vitamin8%

“Didnt help my vitamin b levels”

Functionality-Overall8%

“No results”

Value For Money7%

“Waste of money”

Side Effects6%

“my heart started racing”

Taste-Overall5%

“it tasted a little gritty”

Quality-Overall5%

“Filing formal complaints”

Sleep Quality3%

“Did not make me feel any better more tired”

Stress/Anxiety2%

“EXTREME ANXIETY”

Allergies2%

“then my entire body started itching to the point I was covered in hives”

Top return reasons

Quality-Overall13%

Ease Of Use13%

Heart Health13%

Product Condition13%

Natural Ingredients13%

Dosage13%

Calcium13%

Color6%

Rusts/Corrodes6%

Common methylation questions

Is methylation profitable to sell on Amazon United States?: The niche generates $344K/yr across 17 tracked products. 90-day search growth is -20.6%. Flapen's verdict: Worth a look (51/100).
How competitive is the methylation niche?: 7 brands and 9 sellers compete. The top 5 products take 72% of clicks and top 5 brands hold 95% of demand.
What do buyers complain about in methylation?: Top complaints mined from reviews: Dosage, Vitamin, Functionality-Overall. The return rate is 0.0%.
What does it cost to enter the methylation niche?: Listings span $21.67–$61.16; the average listing price is $45.24 (sweet spot $15–$100). The average incumbent carries 1,253 reviews — the moat a new listing must climb.