Methyl Cpg
Skip itA small market ($34K/yr) — this niche doesn't clear our bar today.
Returns
Incredible0.0%return rate — above 5% kills the launch gate
Avg price
Great$48.42avg listing price — sweet spot $15–$100
Conversion
Good5.3%search→purchase rate — share of searches ending in a sale
Brand share
Good70%top-5 brand share — brands hold most of the demand
Growth
Good+32.1%90-day search growth — must beat 0% to launch
Review moat
Okay1,960.42avg incumbent reviews — the moat a new listing must climb
Price range
Okay$12.00–$202.71cheapest to priciest tracked listing — scored on the share inside $15–$100
Competition
Okay63%top-5 click share — leaders hold, buyers still browse
Quality gap
Bad4.7★avg incumbent rating — lower means beatable quality
Market size
Bad$34K$34K/yr · 13K searches
Is methyl cpg profitable on Amazon?
According to Flapen's Amazon United States niche tracking, methyl cpg is a $34K/yr Amazon United States market (13K searches/yr). The top 5 brands hold 70% of demand. Demand peaks in Jan–Sep–Oct–Nov. Verdict: Skip it — 48/100.
Data updated Jul 28, 2026 · scored weekly · How we score niches
methyl cpg market size & sales
Units sold, revenue, conversion and listing quality across the tracked shelf.- Units sold / yr
- 500–750
- avg 0–100/product
- Revenue / yr
- $24K–$36K
- units × avg price
- Conversion rate
- 5.3%
- Avg BSR
- #146
- Page quality
- 0%
- Prime
- 89%
- Sponsored
- 89%
- Out of stock
- 0.0%
- Avg brand age
- 95 months
- Avg seller age
- 163 days
Competition: brands, sellers & click share
The top 5 products take 63% of clicks — established leaders, but buyers still shop beyond them.Brands
13 falling
Sellers
37
Top-5 brand share
70%
Top 20: 100%
Top-5 click share
63%
Top 20: 100%
Open market
22%
- Ortho Molecular Products21%
- THORNE20%
- Triquetra Health10%
- Pure Encapsulations9%
- Pure Therapro Rx9%
- Micro Ingredients8%
methyl cpg demand & seasonality
Weekly Amazon search volume, last 99 weeks — +32.1% search growth over the last 90 days.Peak months: Jan, Sep, Oct, Nov · busiest ÷ quietest = 2.4×
Top methyl cpg products & what they sell for
Every tracked product — its share of the shelf, its review moat, and what it sells for.Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
All 19 tracked products in this niche — three views at once, no toggling.
Top sellers
by 90-day click share
Ortho Molecular Products Methyl CpG 60 capsules (Pack of 3)
Ortho Molecular Products$202.714.7★89 rev
THORNE - Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2 B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten Dairy & Soy-Free - 30 Servings
THORNE$60.664.7★1,776 rev
Pure Encapsulations MethylAssist 90s - B Vitamin Complex - Methylation Support* - Heart Health & Brain Health - Non-GMO & Gluten Free - 90 Capsules
Pure Encapsulations$61.164.6★480 rev
Methylated B Complex Vitamins Made in USA 2 Month Supply Methyl B Complete Quatrefolic 5-MTHF Folate B12 Methylcobalamin TMG Trimethylglycine Methylfolate Pharm Grade 60 Count
Pure Therapro Rx$31.144.7★2,617 rev
L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$21.674.6★9,407 rev
Newest
by launch date
Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil
Micro Ingredients$28.48289 rev
Nutricost Methylated Vitamin B Complex 120 Capsules 60 Servings
Nutricost$15.65377 rev
Micro Ingredients Pure Methylated B Complex 240 Capsules | 11-in-1 Formula with Methylfolate B12 Thiamin Inositol Choline & Fat Soluble Vitamin C | Clean Ingredients Without Fillers | Non-GMO
Micro Ingredients$24.651,488 rev
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834,077 rev
Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin B6 B12 Folate L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)
Designs for Health$33.99949 rev
Trending
90-day click momentum
Ortho Molecular Ortho B Complex 90
Ortho Molecular Products$67.005.0★
Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin B6 B12 Folate L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)
Designs for Health$33.994.8★
Nutricost Methylated Vitamin B Complex 120 Capsules 60 Servings
Nutricost$15.654.6★
Metagenics MethylCare - Folate L-5-MTHF Methyl B12 B6 NAC & Betaine HCl - Supports Homocysteine Metabolism Methylation & Heart Health - Non-GMO & Gluten-Free - 120 Capsules
Metagenics$44.234.8★
Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil
Micro Ingredients$28.484.8★
What reviews say buyers love and hate about methyl cpg
What buyers praise and complain about, mined from review topics.What buyers love
“Good quality suppliment”
“Great vitamin”
“Worth it”
“As advertised”
“It helps with energy”
“My focus is better”
“Effective”
“Ease”
“has all the B's in great amount”
“Easy to swallow pill”
What buyers complain about
“Unless you've been specifically instructed by a doctor to take this high of a dosage”
“Way too much Vitamin B9 and B12”
“No results”
“However, the taste is off”
“Over Priced”
“It made my anxiety and agitation worse and I felt very ill”
“The smell is a bit overpowering”
“Caused insomnia”
“Allergic reaction”
“Seemed to cause anxiety”
Top return reasons
Common methyl cpg questions
- Is methyl cpg profitable to sell on Amazon United States?
- The niche generates $34K/yr across 19 tracked products. 90-day search growth is +32.1%. Flapen's verdict: Skip it (48/100).
- How competitive is the methyl cpg niche?
- 13 brands and 37 sellers compete. The top 5 products take 63% of clicks and top 5 brands hold 70% of demand.
- What do buyers complain about in methyl cpg?
- Top complaints mined from reviews: Dosage, Vitamin, Functionality-Overall. The return rate is 0.0%.
- When does demand for methyl cpg peak?
- Demand peaks in Jan–Sep–Oct–Nov; the busiest month runs 2.4× the quietest.
- What does it cost to enter the methyl cpg niche?
- Listings span $12.00–$202.71; the average listing price is $48.42 (sweet spot $15–$100). The average incumbent carries 1,960 reviews — the moat a new listing must climb.