Is lysine cold sore treatment profitable to sell on Amazon United States?

The niche generates $649K/yr across 15 tracked products. 90-day search growth is -22.2%. Flapen's verdict: Worth a look (50/100).

How competitive is the lysine cold sore treatment niche?

12 brands and 562 sellers compete. The top 5 products take 72% of clicks and top 5 brands hold 82% of demand.

What do buyers complain about in lysine cold sore treatment?

Top complaints mined from reviews: Size-Overall, Adhesion/Stickiness, Functionality-Overall. The return rate is 0.1%.

When does demand for lysine cold sore treatment peak?

Demand peaks in Jan–Feb–Dec; the busiest month runs 2.2× the quietest.

What does it cost to enter the lysine cold sore treatment niche?

Listings span $6.54–$38.79; the average listing price is $13.28 (sweet spot $15–$100). The average incumbent carries 7,137 reviews — the moat a new listing must climb.

Lysine Cold Sore Treatment

Worth a look

Shows low returns (0.1%), but soft demand (-22.2% this quarter) keeps it on the watch list.

Returns

Incredible0.1%

return rate — above 5% kills the launch gate

Conversion

Incredible15.9%

search→purchase rate — share of searches ending in a sale

Price range

Good$6.54–$38.79

cheapest to priciest tracked listing — scored on the share inside $15–$100

Market size

Good$649K

$649K/yr · 308K searches

Avg price

Good$13.28

avg listing price — sweet spot $15–$100

Brand share

Okay82%

top-5 brand share — brands hold most of the demand

Quality gap

Okay4.5★

avg incumbent rating — lower means beatable quality

Competition

Bad72%

top-5 click share — a locked-up shelf

Review moat

Bad7,136.6

avg incumbent reviews — the moat a new listing must climb

Growth

Bad-22.2%

90-day search growth — must beat 0% to launch

Is lysine cold sore treatment profitable on Amazon?

According to Flapen's Amazon United States niche tracking, lysine cold sore treatment is a $649K/yr Amazon United States market (308K searches/yr). The top 5 brands hold 82% of demand. Demand peaks in Jan–Feb–Dec. Verdict: Worth a look — 50/100.

Data updated Jul 11, 2026 · scored weekly · How we score niches

lysine cold sore treatment market size & sales

Units sold, revenue, conversion and listing quality across the tracked shelf.

Units sold / yr: 50K–60K; avg 3,000–4,000/product
Revenue / yr: $664K–$797K; units × avg price
Conversion rate: 15.9%
Avg BSR: #161
Page quality: 0%
Prime: 100%
Sponsored: 87%
Out of stock: 0.0%
Avg brand age: 75 months
Avg seller age: 145 days

Competition: brands, sellers & click share

The top 5 products capture 72% of clicks — a locked-up shelf that new listings rarely crack.

Brands

12 rising

Sellers

562

Top-5 brand share

82%

Top 20: 100%

Top-5 click share

72%

Top 20: 100%

Open market

15%

Quantum54%
Basic Organics12%
NOW Foods7%
Herpecin-L5%
Clear Probiotics5%
Basic Brands3%
Open — no brand owns it (6 brands, 15%)

lysine cold sore treatment demand & seasonality

Weekly Amazon search volume, last 104 weeks — -22.2% search growth over the last 90 days.

Peak months: Jan, Feb, Dec · busiest ÷ quietest = 2.2×

Open Trend

Top lysine cold sore treatment search terms shoppers use

The exact queries shoppers type, with yearly volume, growth and conversion.

lysine cold sore treatment120K/yr -23.2%15.4% conv.
lysine lip balm81K/yr -22.3%14.9% conv.
lysine chapstick17K/yr -22.7%13.1% conv.
cold sore prevention8K/yr -5.8%7.3% conv.
lysine lip8K/yr -25.7%16.1% conv.
l lysine lip balm9K/yr -29.1%13.1% conv.
lysine lip balm cold sore4K/yr +19.5%1.3% conv.
lysine cold sore6K/yr -28.4%16.5% conv.
lysine lip clear6K/yr -37.2%21.7% conv.
lysine for cold sores9K/yr -33.8%13.2% conv.

All search terms

Top lysine cold sore treatment products & what they sell for

Every tracked product — its share of the shelf, its review moat, and what it sells for.

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 15 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

Quantum$7.604.6★5,884 rev

Basic Brands Lysine Lip Balm Cold Sore & Herpes Simplex Treatment

Basic Organics$10.744.6★4,976 rev

Quantum Health SuperLysine+ Coldstick Lip Sunscreen - Lysine Herbs & Nutrients Soothe & Moisturize Lips - Softens & Protects from the Sun - SPF 21 - Clear - 0.17 Ounce

Quantum$7.674.6★1,525 rev

NOW Foods Supplements (L-Lysine Hydrochloride) 1 000 mg Double Strength Amino Acid 100 Tablets

NOW Foods$8.524.6★37,975 rev

Herpecin-L Everyday Protection Lip Balm Stick SPF 30 - Relief from Cold Sores Fever Blisters and Chapped Lips with Lemon Balm 0.1oz

Herpecin-L$6.734.6★11,909 rev

Newest

by launch date

Lyranda - Lysine Cold Sore Treatment - Chewable L-Lysine Tablets - Faster Absorption and Better Hygiene

Lyranda$20.17757 rev

2y ago

Mederma Cold Sore Discreet Patch - Hydrocolloid Gel Relieves Redness & Swelling Conceals Cold Sores

Mederma$13.0612,947 rev

5y ago

Lysine Cold Sore Treatment for Lips with Pre-Probiotics & VIT C | 1 Month Supply | Supercharged Lysine Capsules with Rhamnosus & Acidophilus for Cold Sores Relief Skin + Gut Health & Immune Support

Clear Probiotics$38.79778 rev

6y ago

100% PURE Lysine + Herbs Healing Lip Balm Natural Soothing Nourishment for Sore Cracked Chapped or Irritated Lips - Natural Dry Lip Hydration Therapy for Women & Men

100% PURE$7.94636 rev

7y ago

Super Lysine Plus+ ColdStick SPF 21 Regular 0.18 oz (Pack of 3) by Quantum Research

Quantum$20.11920 rev

10y ago

What reviews say buyers love and hate about lysine cold sore treatment

What buyers praise and complain about, mined from review topics.

What buyers love

Quality-Overall15%

“Excellent product”

Efficiency11%

“it works QUICKLY”

Cold Relief10%

“It prevents cold sores”

Value For Money8%

“Good value”

Pain Relief-Overall4%

“No pain at all”

Moist/Dry4%

“Very effective and moisturizing”

Advertised Vs Actual Product4%

“Works as advertised”

Fever Relief3%

“Good for fever blisters”

Vitamin2%

“Quality vitamins”

Soft Feel2%

“Creamy and smooth”

What buyers complain about

Size-Overall9%

“They are larger”

Adhesion/Stickiness7%

“They're very sticky”

Functionality-Overall7%

“It didnt help”

Taste-Overall6%

“Has a weird aftertaste”

Pain Relief-Overall5%

“more painful then they typically are”

Value For Money4%

“Waste of money”

Allergies4%

“I must be allergic”

Ease Of Use4%

“Very hard to use”

Ease Of Chewing/Swallowing4%

“Stay away; Impossible to swallow”

Moist/Dry3%

“started drying out”

Top return reasons

Functionality-Overall17%

Advertised Vs Actual Product13%

Product Condition10%

Value For Money10%

Smell9%

Texture/Consistency-Overall6%

Ingredients-Overall5%

Certifications3%

Leak-Proof3%

Adhesion/Stickiness2%

Common lysine cold sore treatment questions

Is lysine cold sore treatment profitable to sell on Amazon United States?: The niche generates $649K/yr across 15 tracked products. 90-day search growth is -22.2%. Flapen's verdict: Worth a look (50/100).
How competitive is the lysine cold sore treatment niche?: 12 brands and 562 sellers compete. The top 5 products take 72% of clicks and top 5 brands hold 82% of demand.
What do buyers complain about in lysine cold sore treatment?: Top complaints mined from reviews: Size-Overall, Adhesion/Stickiness, Functionality-Overall. The return rate is 0.1%.
When does demand for lysine cold sore treatment peak?: Demand peaks in Jan–Feb–Dec; the busiest month runs 2.2× the quietest.
What does it cost to enter the lysine cold sore treatment niche?: Listings span $6.54–$38.79; the average listing price is $13.28 (sweet spot $15–$100). The average incumbent carries 7,137 reviews — the moat a new listing must climb.