Is endometriosis pain relief profitable to sell on Amazon United States?

The niche generates $3.5M/yr across 10 tracked products. 90-day search growth is -3.3%. Flapen's verdict: Worth a look (50/100).

How competitive is the endometriosis pain relief niche?

4 brands and 53 sellers compete. The top 5 products take 81% of clicks and top 5 brands hold 100% of demand.

What do buyers complain about in endometriosis pain relief?

Top complaints mined from reviews: Functionality-Overall, Dosage, Muscle Pain Relief. The return rate is 0.0%.

When does demand for endometriosis pain relief peak?

Demand peaks in Feb–Mar–Apr–May–Jun; the busiest month runs 7.3× the quietest.

What does it cost to enter the endometriosis pain relief niche?

Listings span $5.62–$42.67; the average listing price is $13.20 (sweet spot $15–$100). The average incumbent carries 6,238 reviews — the moat a new listing must climb.

endometriosis pain relief

Worth a look

Shows searches that convert (20.8% search→purchase), but brand-locked demand (top 5 brands take 100% of clicks) keeps it on the watch list.

Conversion

Incredible20.8%

search→purchase rate — share of searches ending in a sale

Returns

Incredible0.0%

return rate — above 5% kills the launch gate

Market size

Incredible$3.5M

$3.5M/yr · 1.3M searches

Price range

Great$5.62–$42.67

cheapest to priciest tracked listing — scored on the share inside $15–$100

Avg price

Good$13.20

avg listing price — sweet spot $15–$100

Review moat

Bad6,238

avg incumbent reviews — the moat a new listing must climb

Growth

Bad-3.3%

90-day search growth — must beat 0% to launch

Quality gap

Bad4.7★

avg incumbent rating — lower means beatable quality

Competition

Bad81%

top-5 click share — a locked-up shelf

Brand share

Bad100%

top-5 brand share — brand-locked demand

According to Flapen's Amazon United States niche tracking, endometriosis pain relief is a $3.5M/yr Amazon United States market (1.3M searches/yr). The top 5 brands hold 100% of demand. Demand peaks in Feb–Mar–Apr–May–Jun. Verdict: Worth a look — 50/100.

Data updated Jul 11, 2026 · scored weekly · How we score niches

endometriosis pain relief market data

Units sold / yr: 250K–300K; avg 20,000–25,000/product
Revenue / yr: $3.3M–$4.0M; units × avg price
Conversion rate: 20.8%
Avg BSR: #93
Page quality: 0%
Prime: 100%
Sponsored: 100%
Out of stock: 0.0%
Avg brand age: 62 months
Avg seller age: 149 days

Competition & brand share

The top 5 products capture 81% of clicks — a locked-up shelf that new listings rarely crack.

Brands

4 flat

Sellers

Top-5 brand share

100%

Top 20: 100%

Top-5 click share

81%

Top 20: 100%

Open market

Midol76%
Pamprin15%
HealthA2Z6%
Cramp Defense3%

Demand & seasonality

Weekly Amazon search volume, last 104 weeks — -3.3% search growth over the last 90 days.

Peak months: Feb, Mar, Apr, May, Jun · busiest ÷ quietest = 7.3×

Open Trend

Top endometriosis pain relief search terms

midol604K/yr -8.8%21.9% conv.
midol complete maximum strength119K/yr +103.1%26.4% conv.
pamprin140K/yr +0.3%16.3% conv.
midol menstrual extra strength128K/yr -60.2%18.5% conv.
pamprin maximum strength51K/yr +1.8%14.2% conv.
cramp defense32K/yr -4.1%17.2% conv.
endometriosis pain relief40K/yr -46.9%0.2% conv.
midol complete25K/yr -19.6%11.7% conv.
midol extra strength17K/yr +9.2%11.4% conv.
pamprin maximum strength multi-symptom menstrual relief tablets15K/yr +15.4%13.5% conv.

All search terms

Top endometriosis pain relief products on Amazon

Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.

Beatable (≤4.3★) Contested Strong incumbent (>4.7★)

All 10 tracked products in this niche — three views at once, no toggling.

Top sellers

by 90-day click share

Midol Complete Menstrual Pain Relief Caplets 40 Count - Provides Cramp Headache and Bloating Relief

Midol$8.254.8★19,404 rev

Pamprin Multi-Symptom Formula with Acetaminophen Menstrual Period Symptoms Relief including Cramps Pain Bloating and Irritability 40 Caplets

Pamprin$6.994.7★10,286 rev

Midol Complete Gelcaps : Midol Complete Menstrual Pain Relief Gelcaps with Acetaminophen for Menstrual Symptom Pms Relief and Period Cramp Relief - 24 Count

Midol$6.424.8★4,745 rev

Midol Complete Menstrual Pain Relief Caplets with Acetaminophen for Period Cramps and Menstrual Symptom Relief - 40 Count (Pack of 3) (Packaging May Vary)

Midol$23.854.8★3,202 rev

HealthA2Z Menstrual Complete Pain Relief Tablets | Relieves Cramps Bloating Fatigue Backache & Headache (120 Counts)

HealthA2Z$10.944.8★900 rev

Newest

by launch date

HealthA2Z Menstrual Complete Pain Relief Tablets | Relieves Cramps Bloating Fatigue Backache & Headache (120 Counts)

HealthA2Z$10.94900 rev

1y ago

Midol Bloat Relief Caplets with Pamabrom Relieve Bloating Symptoms Before and During Your Period Provides Up to 6 Hours of Relief for Women 60 Count

Midol$13.542,774 rev

5y ago

Midol Complete Caffeine Free Caplets 24ct: Midol Complete Caffeine Free Menstrual Pain Relief Caplets with Acetaminophen Provides Headache Relief and Period Cramps Relief 24 Count

Midol$6.312,214 rev

5y ago

Midol Complete Menstrual Pain Relief Caplets with Acetaminophen for Period Cramps and Menstrual Symptom Relief - 40 Count (Pack of 3) (Packaging May Vary)

Midol$23.853,202 rev

7y ago

Midol Long Lasting Relief 20ct: Midol Long Lasting Relief Menstrual Symptom Reliever & Fever Reducer Caplets with Acetaminophen for Menstrual Pain Relief - 20 Count (Packaging May Vary)

Midol$7.453,359 rev

8y ago

What buyers say about endometriosis pain relief

What buyers praise and complain about, mined from review topics.

What buyers love

Muscle Pain Relief19%

“Reducing back pain”

Efficiency13%

“It works, quickly and consistently”

Menstrual Issues10%

“The best product for period cramps”

Quality-Overall7%

“no complaints so far”

Value For Money7%

“Best price”

Joint Pain6%

“My knee pain seems to respond best to Aspirine/tylonol combo”

Caffeine Content4%

“this caffeine free option is great”

Sleep Quality4%

“A good night's sleep”

Ease Of Use2%

“Easy to use”

Advertised Vs Actual Product2%

“Great as advertised”

What buyers complain about

Functionality-Overall15%

“It doesnt help”

Dosage11%

“When I read the back label I was concerned that the dose wasn't high enough”

Muscle Pain Relief10%

“Not defending the cramps”

Value For Money8%

“Pricey”

Pain Relief-Overall7%

“foot cramps waking me up every night”

Sleep Quality6%

“dont take at night”

Side Effects6%

“It only makes my symptoms worse”

Size-Overall3%

“The pill is a bit big”

Magnesium2%

“He has tried high doses of magnesium with no relief”

Regulates Digestion2%

“be warned—it also causes some pretty bad constipation which leads to pain of another kind”

Top return reasons

Size-Overall50%

Ingredients-Overall25%

Muscle Pain Relief25%

Common questions

Is endometriosis pain relief profitable to sell on Amazon United States?: The niche generates $3.5M/yr across 10 tracked products. 90-day search growth is -3.3%. Flapen's verdict: Worth a look (50/100).
How competitive is the endometriosis pain relief niche?: 4 brands and 53 sellers compete. The top 5 products take 81% of clicks and top 5 brands hold 100% of demand.
What do buyers complain about in endometriosis pain relief?: Top complaints mined from reviews: Functionality-Overall, Dosage, Muscle Pain Relief. The return rate is 0.0%.
When does demand for endometriosis pain relief peak?: Demand peaks in Feb–Mar–Apr–May–Jun; the busiest month runs 7.3× the quietest.
What does it cost to enter the endometriosis pain relief niche?: Listings span $5.62–$42.67; the average listing price is $13.20 (sweet spot $15–$100). The average incumbent carries 6,238 reviews — the moat a new listing must climb.