5 mthf plus b12
Skip itA small market ($37K/yr) — this niche doesn't clear our bar today.
Returns
Incredible0.0%return rate — above 5% kills the launch gate
Avg price
Incredible$27.51avg listing price — sweet spot $15–$100
Price range
Great$11.10–$88.17cheapest to priciest tracked listing — scored on the share inside $15–$100
Conversion
Great10.8%search→purchase rate — share of searches ending in a sale
Growth
Good+26.3%90-day search growth — must beat 0% to launch
Review moat
Okay2,883.08avg incumbent reviews — the moat a new listing must climb
Competition
Bad71%top-5 click share — a locked-up shelf
Quality gap
Bad4.6★avg incumbent rating — lower means beatable quality
Brand share
Bad94%top-5 brand share — brand-locked demand
Market size
Bad$37K$37K/yr · 12K searches
According to Flapen's Amazon United States niche tracking, 5 mthf plus b12 is a $37K/yr Amazon United States market (12K searches/yr). The top 5 brands hold 94% of demand. Demand peaks in Jan–Feb–Dec. Verdict: Skip it — 47/100.
Data updated Jul 28, 2026 · scored weekly · How we score niches
5 mthf plus b12 market data
- Units sold / yr
- 2K–2K
- avg 100–250/product
- Revenue / yr
- $41K–$55K
- units × avg price
- Conversion rate
- 10.8%
- Avg BSR
- #82
- Page quality
- 0%
- Prime
- 100%
- Sponsored
- 100%
- Out of stock
- 0.0%
- Avg brand age
- 67 months
- Avg seller age
- 167 days
Competition & brand share
The top 5 products capture 71% of clicks — a locked-up shelf that new listings rarely crack.Brands
8 rising
Sellers
534
Top-5 brand share
94%
Top 20: 100%
Top-5 click share
71%
Top 20: 100%
Open market
4%
- Triquetra Health58%
- Designs for Health16%
- Nutricost10%
- THORNE5%
- Vocks4%
- Pure Encapsulations3%
- Open — no brand owns it (2 brands, 4%)
Demand & seasonality
Weekly Amazon search volume, last 98 weeks — +26.3% search growth over the last 90 days.Peak months: Jan, Feb, Dec · busiest ÷ quietest = 5.9×
Top 5 mthf plus b12 search terms
- 5mthf supplement plus b127K/yr
- l-5-mthf4K/yr
- methylated folic acid and b122K/yr
Top 5 mthf plus b12 products on Amazon
Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
All 13 tracked products in this niche — three views at once, no toggling.
Top sellers
by 90-day click share
L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$21.674.6★9,407 rev
Designs for Health L 5-MTHF - Quatrefolic L Methylfolate Supplement 1mg (1700mcg DFE) - Methylated Folate Supplement for Women & Men - Supports Methylation - Non-GMO Gluten Free (120 Capsules)
Designs for Health$55.434.6★293 rev
L Methyl Folate 15mg Plus Methyl B12 Cofactor Organic Berry Flavor High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms Vitamin B9 & B12 (1oz)
Triquetra Health$21.874.5★5,924 rev
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) Metabolically Active 5-MTHF Form Organic Berry Flavor Liquid Sublingual Form Mood Cognition Methylation Pregnancy (1oz)
Triquetra Health$21.844.6★4,077 rev
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834.6★4,077 rev
Newest
by launch date
Vocks L Methylfolate 15mg | 5-MTHF + Methyl B12 | High Potency Methylfolate Supplement | Active Methylated Folate Vitamin B9 | MTHFR Supplement| Folate Supplement for Women & Men | 90 Capsules
Vocks$12.4597 rev
Nutricost Methylated Vitamin B12 + Folate Supplement (2 000 mcg) 120 Caps
Nutricost$11.10154 rev
Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil
Micro Ingredients$28.48289 rev
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834,077 rev
Nutricost L-Methylfolate 15mg 120 Capsules (5-MTHF) Gluten-Free Vegan
Nutricost$19.72530 rev
Trending
90-day click momentumVocks L Methylfolate 15mg | 5-MTHF + Methyl B12 | High Potency Methylfolate Supplement | Active Methylated Folate Vitamin B9 | MTHFR Supplement| Folate Supplement for Women & Men | 90 Capsules
Vocks$12.454.5★
Nutricost Methylated Vitamin B12 + Folate Supplement (2 000 mcg) 120 Caps
Nutricost$11.104.7★
L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)
Triquetra Health$17.834.6★
Jarrow Formulas Methyl B-12 & Methyl Folate Bioactive Vitamin B9 & Vitamin B12 Supplement Supports Cellular Energy Production Healthy Brain Function & Metabolism 100 Chewable Tablets 100 Servings
Jarrow Formulas$13.684.6★
Nutricost L-Methylfolate 15mg 120 Capsules (5-MTHF) Gluten-Free Vegan
Nutricost$19.724.7★
What buyers say about 5 mthf plus b12
What buyers praise and complain about, mined from review topics.What buyers love
“Quality and ease of use”
“Doesnt taste bad”
“Natural vitamin”
“helps with focus”
“Lots of Energy”
“Effective”
“Just as advertised”
“Good value”
“Easy to use”
“Easy dosages”
What buyers complain about
“Doesn't do anything”
“had some strange side effects”
“The dose on this is a little too high”
“It tastes terrible”
“Way too much Vitamin B9 and B12”
“Its not as good as they make it seem”
“A bit expensive”
“I also couldnt sleep”
“The advertisements are misleading”
“Seemed to cause anxiety”
Top return reasons
Common questions
- Is 5 mthf plus b12 profitable to sell on Amazon United States?
- The niche generates $37K/yr across 13 tracked products. 2 of 2 products launched in the last 360 days are still selling. 90-day search growth is +26.3%. Flapen's verdict: Skip it (47/100).
- How competitive is the 5 mthf plus b12 niche?
- 8 brands and 534 sellers compete. The top 5 products take 71% of clicks and top 5 brands hold 94% of demand.
- What do buyers complain about in 5 mthf plus b12?
- Top complaints mined from reviews: Functionality-Overall, Side Effects, Dosage. The return rate is 0.0%.
- When does demand for 5 mthf plus b12 peak?
- Demand peaks in Jan–Feb–Dec; the busiest month runs 5.9× the quietest.
- What does it cost to enter the 5 mthf plus b12 niche?
- Listings span $11.10–$88.17; the average listing price is $27.51 (sweet spot $15–$100). The average incumbent carries 2,883 reviews — the moat a new listing must climb.