---
title: "Protease — $51K/yr Amazon US Niche (2026) - Flapen"
canonical_url: "https://flapen.com/research/us/health-household/protease"
last_updated: "2026-08-10T18:20:31.209Z"
locale: en
meta:
description: "Niche score 50/100 · $51K/yr market · 40K searches/yr · $32.75 avg price. A small market ($51K/yr) keeps it on the watch list. Data updated Jul 2026."
"og:description": "Niche score 50/100 · $51K/yr market · 40K searches/yr · $32.75 avg price. A small market ($51K/yr) keeps it on the watch list. Data updated Jul 2026."
"og:title": "Protease — $51K/yr Amazon US Niche (2026) - Flapen"
---
# **protease**
**Worth a look**
Shows low returns (0.0%), but a small market ($51K/yr) keeps it on the watch list.
Market size 13Growth 37Conversion 48Competition 56Returns 100Price range 90Avg price 95Brand share 55Review moat 29Quality gap 35
**Returns**
**Incredible****0.0%**
return rate — above 5% kills the launch gate
**Avg price**
**Incredible****$32.75**
avg listing price — sweet spot $15–$100
**Price range**
**Great****$9.96–$86.87**
cheapest to priciest tracked listing — scored on the share inside $15–$100
**Competition**
**Good****51%**
top-5 click share — leaders hold, buyers still browse
**Brand share**
**Good****72%**
top-5 brand share — brands hold most of the demand
**Conversion**
**Okay****3.9%**
search→purchase rate — share of searches ending in a sale
**Growth**
**Okay****+9.6%**
90-day search growth — must beat 0% to launch
**Quality gap**
**Okay****4.5★**
avg incumbent rating — lower means beatable quality
**Review moat**
**Okay****3,641.11**
avg incumbent reviews — the moat a new listing must climb
**Market size**
**Bad****$51K**
$51K/yr · 40K searches
According to Flapen's Amazon United States niche tracking, protease is a $51K/yr Amazon United States market (40K searches/yr). The top 5 brands hold 72% of demand. Verdict: Worth a look — 50/100.
Data updated Jul 26, 2026 · scored weekly · [~~How we score niches ~~](https://flapen.com/research/methodology)
## **protease market data**
- **Units sold / yr**
- **2K–2K**
- avg 0–100/product
- **Revenue / yr**
- **$49K–$66K**
- units × avg price
- **Conversion rate**
- **3.9%**
- **Avg BSR**
- **#713**
- **Page quality**
- **0%**
- **Prime**
- **96%**
- **Sponsored**
- **81%**
- **Out of stock**
- **0.0%**
- **Avg brand age**
- **99 months**
- **Avg seller age**
- **164 days**
## **Competition & brand share**
The top 5 products take 51% of clicks — established leaders, but buyers still shop beyond them.
**Brands**
**17 **▼falling
**Sellers**
**586**
**Top-5 brand share**
**72%**
Top 20: 100%
**Top-5 click share**
**51%**
Top 20: 93%
**Open market**
**22%**
- TRANSFORMATION29% - NOW Foods19% - Physician's CHOICE9% - Pure Encapsulations8% - NESS7% - Double Wood Supplements6%
## **Demand & seasonality**
Weekly Amazon search volume, last 102 weeks — +9.6% search growth over the last 90 days.
900700Spike '25Spike '26 seasonSepDecMarJunAugNovMarMay
No pronounced peak months · busiest ÷ quietest = 1.2×
[**Open Trend **](https://flapen.com/research/us/health-household/protease/trend)
## **Top protease search terms**
- **protease**16K/yr+15.9%3.2% conv. - **protease enzyme supplement**13K/yr-6.5%5.6% conv. - **protease enzyme**4K/yr+143.3%2.4% conv. - **amylase lipase protease enzyme**3K/yr-2.3%4.3% conv. - **protease enzymes**4K/yr-53.8%2.2% conv. [**All search terms **](https://flapen.com/research/us/health-household/protease/search-terms)
## **Top protease products on Amazon**
Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
0%5%$3K10%$5K15%$8K20%$10K101001K10K100K Reviews — right = deep review moatMarket share (90d) ≈ est. sales
Beatable (≤4.3★) Contested Strong incumbent (>4.7★)
All 24 tracked products in this niche — three views at once, no toggling.
### **Top sellers**
by 90-day click share
[1**TRANSFORMATION THE GENESIS OF GOOD HEALTH Protease 375K Enzyme Blend Supplement High-Potency Formula for Protein Absorption & Gut Health Advanced Enzym Support Non-GMO 60 Capsules**TRANSFORMATION**$45.14**4.4★205 rev](https://www.amazon.com/dp/B00CE8TMW8) [2**NOW Supplements Pancreatin 10X 200 mg with naturally occurring Protease (Protein Digesting) Amylase (Carbohydrate Digesting) and Lipase (Fat Digesting) Enzymes 100 Capsules**NOW Foods**$11.86**4.6★4,659 rev](https://www.amazon.com/dp/B001F0R7QY) [3**Physicians CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16 Enzyme Formula with Organic Prebiotics & Probiotics for Gut & Digestive Health - Meal Time Discomfort Relief - 60 CT**Physician's CHOICE**$19.08**4.5★18,747 rev](https://www.amazon.com/dp/B0C21ZLQNC) [4**Ness Protease | Single Enzyme Digestive Supplement | Supports Protein Digestion | 180 Vegetarian Capsules**NESS**$25.16**4.4★39 rev](https://www.amazon.com/dp/B005HXTYY8) [5**TRANSFORMATION THE GENESIS OF GOOD HEALTH Enzymes - Protease Digestive Supplement Advanced Formula Supports Healthy Digestion Immunity Nutrient Absorption Improve Tolerance On an Empty Stomach**TRANSFORMATION**$86.87**4.5★209 rev](https://www.amazon.com/dp/B008JHYI1S)
**~~View all top sellers →~~**
### **Newest**
by launch date
[**Digestive Enzymes Supplement for Men High Potency Pancreatin 4X Formula with Amylase Protease & Lipase Enzymes for Digestion Bloating Relief & Gut Health 50 Capsules**Vimerson Health**$16.49**27 rev3mo ago](https://www.amazon.com/dp/B0GK35MPVK) [**TRANSFORMATION THE GENESIS OF GOOD HEALTH Protease 375K Enzyme Blend Supplement High-Potency Formula for Protein Absorption & Gut Health Advanced Enzym Support for Nuttrient Absorption Non-GMO 120**TRANSFORMATION**$82.21**205 rev2y ago](https://www.amazon.com/dp/B0CGRY29C8) [**Physicians CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16 Enzyme Formula with Organic Prebiotics & Probiotics for Gut & Digestive Health - Meal Time Discomfort Relief - 60 CT**Physician's CHOICE**$19.08**18,747 rev3y ago](https://www.amazon.com/dp/B0C21ZLQNC) [**Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase Lipase Bromelain Lactase Papain Protease Cellulase Maltase Invertase) by Double Wood**Double Wood Supplements**$18.12**3,836 rev5y ago](https://www.amazon.com/dp/B0971P79G2) [**Wonder Laboratories Proteolytic Enzymes | Bromelain Papain Pancreatin Trypsin 550 mg Total with Standardized Amylase Lipase and Protease 100 Tablets**Wonder Laboratories**$9.96**787 rev6y ago](https://www.amazon.com/dp/B089WK945R)
**~~View all new products →~~**
### **Trending**
90-day click momentum
[**Digestive Enzymes Supplement for Men High Potency Pancreatin 4X Formula with Amylase Protease & Lipase Enzymes for Digestion Bloating Relief & Gut Health 50 Capsules**Vimerson Health**$16.49**4.6★**▲ 308%**](https://www.amazon.com/dp/B0GK35MPVK) [**Enzymedica Digest Complete - Helps Gas & Bloating - 90 Caps**Enzymedica**$27.77**4.7★**▲ 266%**](https://www.amazon.com/dp/B00028ORU4) [**Enzymedica Lypo Gold - Protease Amylase & Lipase Digestive Enzymes for Women & Men Enzyme Supplement for Fat Digestion Gut Health & Gallbladder Support Helps Gas & Bloating Gluten Free - 60 Caps**Enzymedica**$22.37**4.4★**▲ 159%**](https://www.amazon.com/dp/B00124UKJ4) [**BSG Amylase Enzyme Formula 1 lb**BSG**$13.06**4.7★**▲ 138%**](https://www.amazon.com/dp/B01N9NQYQR) [**Nutricost Digestive Enzymes (620mg) 120 Capsules**Nutricost**$19.31**4.6★**▲ 117%**](https://www.amazon.com/dp/B074P9J29V)
**~~View all trending →~~**
## **What buyers say about protease**
What buyers praise and complain about, mined from review topics.
### **What buyers love **
**Regulates Digestion**32%
*“Digestive aid”*
**Quality-Overall**13%
*“Good product and very effective”*
**Efficiency**10%
*“Works Well”*
**Acid Regulator/Stomach Ache Relief**9%
*“Great for indigestion”*
**Nutritional Content**4%
*“Great supplement”*
**Value For Money**4%
*“Good Price”*
**Advertised Vs Actual Product**3%
*“Works as advertised”*
**Vitamin**2%
*“Great supplement”*
**Ingredients-Overall**1%
*“They seem to have great ingredients”*
**Side Effects**1%
*“There was noticeably less discomfort when I took these”*
### **What buyers complain about **
**Functionality-Overall**15%
*“they dont work very well”*
**Regulates Digestion**12%
*“had significant digestive discomfort every single time”*
**Acid Regulator/Stomach Ache Relief**12%
*“upsets your stomach”*
**Side Effects**5%
*“It made me nauseous”*
**Allergies**4%
*“Allergic to it”*
**Ingredients-Overall**4%
*“just too many unhealthy ingredients”*
**Dosage**4%
*“not good it doesnt do anything been take one capsule a day”*
**Pain Relief-Overall**3%
*“Terrible terrible pain”*
**Value For Money**3%
*“Expensive”*
**Nutritional Content**2%
*“NOT GLUTEN FREE”*
### **Top return reasons **
**Functionality-Overall**27%
**Value For Money**17%
**Advertised Vs Actual Product**8%
**Color**8%
**Side Effects**4%
**Regulates Digestion**4%
**Smell**4%
**Stale/Rotten/Spoiled**4%
**Accuracy-Overall**4%
**Joint Pain**4%
## **Common questions**
- **Is protease profitable to sell on Amazon United States?**
- The niche generates $51K/yr across 27 tracked products. 0 of 1 products launched in the last 360 days are still selling. 90-day search growth is +9.6%. Flapen's verdict: Worth a look (50/100).
- **How competitive is the protease niche?**
- 17 brands and 586 sellers compete. The top 5 products take 51% of clicks and top 5 brands hold 72% of demand.
- **What do buyers complain about in protease?**
- Top complaints mined from reviews: Functionality-Overall, Regulates Digestion, Acid Regulator/Stomach Ache Relief. The return rate is 0.0%.
- **When does demand for protease peak?**
- Demand is steady year-round — the busiest month runs 1.2× the quietest.
- **What does it cost to enter the protease niche?**
- Listings span $9.96–$86.87; the average listing price is $32.75 (sweet spot $15–$100). The average incumbent carries 3,641 reviews — the moat a new listing must climb.
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