---
title: "Mthfr Test — $13K/mo Amazon US Product Research (2026)"
canonical_url: "https://flapen.com/research/us/health-household/mthfr-test"
last_updated: "2026-08-12T10:59:29.778Z"
locale: en
meta:
description: "Amazon product research for mthfr test: $13K/mo market, demand, competition, pricing, reviews & the verdict. Know if it's worth selling — Flapen."
"og:description": "Amazon product research for mthfr test: $13K/mo market, demand, competition, pricing, reviews & the verdict. Know if it's worth selling — Flapen."
"og:title": "Mthfr Test — $13K/mo Amazon US Product Research (2026)"
---
# **Mthfr Test**
**Skip it**
A concentrated shelf (top 5 take 93% of clicks) — this niche doesn't clear our bar today.
Market size 32Growth 16Conversion 22Competition 6Returns 100Price range 47Avg price 67Brand share 7Review moat 24Quality gap 70
**Returns**
**Incredible****0.1%**
return rate — above 5% kills the launch gate
**Quality gap**
**Good****4.3★**
avg incumbent rating — lower means beatable quality
**Avg price**
**Good****$122.74**
avg listing price — sweet spot $15–$100
**Price range**
**Okay****$21.64–$187.61**
cheapest to priciest tracked listing — scored on the share inside $15–$100
**Market size**
**Okay****$151K**
$151K/yr · 72K searches
**Review moat**
**Bad****6,655.71**
avg incumbent reviews — the moat a new listing must climb
**Conversion**
**Bad****1.7%**
search→purchase rate — share of searches ending in a sale
**Growth**
**Bad****-17.2%**
90-day search growth — must beat 0% to launch
**Brand share**
**Bad****97%**
top-5 brand share — brand-locked demand
**Competition**
**Bad****93%**
top-5 click share — a locked-up shelf
**Signals**[** Low Review Barrier**](https://flapen.com/research/niches?market=us&signal=low_review_barrier "Top brand's reviews < 500") [** High Price**](https://flapen.com/research/niches?market=us&signal=high_price "Avg price > $50")
## **Is mthfr test profitable on Amazon?**
According to Flapen's Amazon United States niche tracking, mthfr test is a $151K/yr Amazon United States market (72K searches/yr). The top 5 brands hold 97% of demand. Verdict: Skip it — 35/100.
Data updated Jul 14, 2026 · scored weekly · [~~How we score niches ~~](https://flapen.com/research/methodology)
## **mthfr test market size & sales**
Units sold, revenue, conversion and listing quality across the tracked shelf.
- **Units sold / yr**
- **1K–2K**
- avg 0–100/product
- **Revenue / yr**
- **$153K–$184K**
- units × avg price
- **Conversion rate**
- **1.7%**
- **Avg BSR**
- **#27**
- **Page quality**
- **0%**
- **Prime**
- **100%**
- **Sponsored**
- **100%**
- **Out of stock**
- **0.0%**
- **Avg brand age**
- **56 months**
- **Avg seller age**
- **158 days**
## **Competition: brands, sellers & click share**
The top 5 products capture 93% of clicks — a locked-up shelf that new listings rarely crack.
**Brands**
**6 **▼falling
**Sellers**
**9**
**Top-5 brand share**
**97%**
Top 20: 100%
**Top-5 click share**
**93%**
Top 20: 100%
**Open market**
**0%**
- empowerDX55% - MTHFR20% - PlexusDX13% - Triquetra Health5% - Accentrate5% - 23andMe3%
## **mthfr test demand & seasonality**
Weekly Amazon search volume, last 104 weeks — -17.2% search growth over the last 90 days.
3K2KSpike '24Spike '25Spike '26 seasonSepDecMarJunAugNovMarMay
No pronounced peak months · busiest ÷ quietest = 1.4×
[**Open Trend **](https://flapen.com/research/us/health-household/mthfr-test/trend)
## **Top mthfr test search terms shoppers use**
The exact queries shoppers type, with yearly volume, growth and conversion.
- **mthfr testing kit at home**11K/yr+67.9%1.6% conv. - **mthfr gene mutation test**17K/yr-16.0%1.9% conv. - **mthfr test**7K/yr+33.3%1.2% conv. - **mthfr testing kit**23K/yr-79.2%0.9% conv. - **mthfr gene test kit**5K/yr+3.4%1.1% conv. - **mthfr gene testing kit**3K/yr+195.9%1.4% conv. - **mthfr gene test**3K/yr-39.9%0.3% conv. - **gene testing kit mthfr**3K/yr+21.6%0.0% conv. [**All search terms **](https://flapen.com/research/us/health-household/mthfr-test/search-terms)
## **Top mthfr test products & what they sell for**
Every tracked product — its share of the shelf, its review moat, and what it sells for.
Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
0%15%$23K30%$45K45%$68K60%$91K101001K10K100K Reviews — right = deep review moatMarket share (90d) ≈ est. sales
Beatable (≤4.3★) Contested Strong incumbent (>4.7★)
All 7 tracked products in this niche — three views at once, no toggling.
### **Top sellers**
by 90-day click share
[1**empowerDX MTHFR Gene Test Kit Methylation Test Easy At-Home Test Detects Presence of 677 and 1298 MTHFR Gene Variants Ages 2+ Fast Results Within 6 Days**empowerDX**$117.63**4.3★160 rev](https://www.amazon.com/dp/B09SGP2P7G) [2**MTHFR-Gene Methylation Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week MTHFR C677T and MTHFR A1298C Gene Variants for Methylation Analysis. Results in 2-5 Days. Ages 0+**MTHFR**$127.07**4.5★126 rev](https://www.amazon.com/dp/B07DMVV76W) [3**Genetic Methylation Test Kit & MTHFR Testing Kit | 300+ DNA Reports Including MTHFR Gene Variants COMT BHMT AHCY and Folate | Custom Supplement & Meal Plan Recommendations with 10 000 Recipes**PlexusDX**$177.86**3.9★83 rev](https://www.amazon.com/dp/B0DNR9RPWF) [4**MTHFR+COMT Methylation Genes Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week. Includes C677T A1298C & V158M Variants for Methylation and Wellness Analysis. Results in 2-5 Days. Ages 0+**MTHFR**$187.61**4.4★68 rev](https://www.amazon.com/dp/B07DMVHM25) [5**L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$21.64**4.6★9,275 rev](https://www.amazon.com/dp/B0938NKV1G)
**~~View all top sellers →~~**
### **Newest**
by launch date
[**MTHFR Gene Test Kit: At-Home DNA Folate Methylation COMT Analysis & Genetic Health Insights Easy Cheek Swab**Accentrate**$119.98**19 rev4mo ago](https://www.amazon.com/dp/B0GS3MKXLB) [**Genetic Methylation Test Kit & MTHFR Testing Kit | 300+ DNA Reports Including MTHFR Gene Variants COMT BHMT AHCY and Folate | Custom Supplement & Meal Plan Recommendations with 10 000 Recipes**PlexusDX**$177.86**83 rev1y ago](https://www.amazon.com/dp/B0DNR9RPWF) [**MTHFR-Gene Methylation Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week MTHFR C677T and MTHFR A1298C Gene Variants for Methylation Analysis. Results in 2-5 Days. Ages 0+**MTHFR**$127.07**126 rev2y ago](https://www.amazon.com/dp/B07DMVV76W) [**empowerDX MTHFR Gene Test Kit Methylation Test Easy At-Home Test Detects Presence of 677 and 1298 MTHFR Gene Variants Ages 2+ Fast Results Within 6 Days**empowerDX**$117.63**160 rev4y ago](https://www.amazon.com/dp/B09SGP2P7G) [**L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$21.64**9,275 rev5y ago](https://www.amazon.com/dp/B0938NKV1G)
**~~View all new products →~~**
### **Trending**
90-day click momentum
[**MTHFR Gene Test Kit: At-Home DNA Folate Methylation COMT Analysis & Genetic Health Insights Easy Cheek Swab**Accentrate**$119.98**4.0★**▲ 448%**](https://www.amazon.com/dp/B0GS3MKXLB) [**L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$21.64**4.6★**▲ 57%**](https://www.amazon.com/dp/B0938NKV1G) [**empowerDX MTHFR Gene Test Kit Methylation Test Easy At-Home Test Detects Presence of 677 and 1298 MTHFR Gene Variants Ages 2+ Fast Results Within 6 Days**empowerDX**$117.63**4.3★**▲ 13%**](https://www.amazon.com/dp/B09SGP2P7G) [**23andMe Health + Ancestry Service: DNA Test Kit FDA-Authorized Reports Genetic Test Health Predispositions Carrier Status Family Tree (Before You Buy See Important Test Info Below)**23andMe**$107.41**4.6★**— 2%**](https://www.amazon.com/dp/B01G7PYQTM) [**MTHFR+COMT Methylation Genes Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week. Includes C677T A1298C & V158M Variants for Methylation and Wellness Analysis. Results in 2-5 Days. Ages 0+**MTHFR**$187.61**4.4★**▼ 14%**](https://www.amazon.com/dp/B07DMVHM25)
**~~View all trending →~~**
## **What reviews say buyers love and hate about mthfr test**
What buyers praise and complain about, mined from review topics.
### **What buyers love **
**Quality-Overall**17%
*“Very reliable”*
**Vitamin**12%
*“Good B vitamin supplement”*
**Ease Of Use**10%
*“easy to operate”*
**Value For Money**9%
*“Great deal”*
**Advertised Vs Actual Product**6%
*“Just as advertised”*
**Energy Level**6%
*“Helps with energy”*
**Focus Enhancement**5%
*“My focus is better”*
**Efficiency**4%
*“Works well”*
**Instructions/User Manual/Troubleshooting**3%
*“the instructions were easy to follow”*
**Fertility/Conception**2%
*“Good for people with the MTHFR gene mutation”*
### **What buyers complain about **
**Value For Money**11%
*“Not worth the Money”*
**Functionality-Overall**10%
*“No results”*
**Dosage**7%
*“Unless you've been specifically instructed by a doctor to take this high of a dosage”*
**Vitamin**6%
*“Way too much Vitamin B9 and B12”*
**Side Effects**5%
*“my heart started racing”*
**Sleep Quality**5%
*“Did not make me feel any better more tired”*
**Quality-Overall**4%
*“Low quality”*
**Accuracy-Overall**4%
*“not really useful results”*
**Nutritional Content**3%
*“Maybe it makes a difference if you have a poor diet”*
**Contamination**3%
*“Im not into swallowing glass so in the trash they go”*
### **Top return reasons **
**Advertised Vs Actual Product**20%
**Certifications**16%
**Value For Money**11%
**Dosage**11%
**Product Condition**9%
**Compatibility-Overall**7%
**Functionality-Overall**4%
**Quality-Overall**4%
**Accuracy-Overall**4%
**Magnesium**4%
## **Common mthfr test questions**
- **Is mthfr test profitable to sell on Amazon United States?**
- The niche generates $151K/yr across 7 tracked products. 0 of 1 products launched in the last 360 days are still selling. 90-day search growth is -17.2%. Flapen's verdict: Skip it (35/100).
- **How competitive is the mthfr test niche?**
- 6 brands and 9 sellers compete. The top 5 products take 93% of clicks and top 5 brands hold 97% of demand.
- **What do buyers complain about in mthfr test?**
- Top complaints mined from reviews: Value For Money, Functionality-Overall, Dosage. The return rate is 0.1%.
- **When does demand for mthfr test peak?**
- Demand is steady year-round — the busiest month runs 1.4× the quietest.
- **What does it cost to enter the mthfr test niche?**
- Listings span $21.64–$187.61; the average listing price is $122.74 (sweet spot $15–$100). The average incumbent carries 6,656 reviews — the moat a new listing must climb.
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