---
title: "Mthfr Supplement — $150K/mo Amazon US Product Research"
canonical_url: "https://flapen.com/research/us/health-household/mthfr-supplement"
last_updated: "2026-08-12T10:21:33.497Z"
locale: en
meta:
description: "Amazon product research for mthfr supplement: $150K/mo market, demand, competition, pricing, reviews & the verdict. Know if it's worth selling — Flapen."
"og:description": "Amazon product research for mthfr supplement: $150K/mo market, demand, competition, pricing, reviews & the verdict. Know if it's worth selling — Flapen."
"og:title": "Mthfr Supplement — $150K/mo Amazon US Product Research"
---
# **Mthfr Supplement**
**Worth a look**
Shows low returns (0.0%), but brand-locked demand (top 5 brands take 100% of clicks) keeps it on the watch list.
Market size 92Growth 44Conversion 95Competition 13Returns 100Price range 95Avg price 95Brand share 0Review moat 32Quality gap 24
**Returns**
**Incredible****0.0%**
return rate — above 5% kills the launch gate
**Conversion**
**Great****12.0%**
search→purchase rate — share of searches ending in a sale
**Avg price**
**Incredible****$29.78**
avg listing price — sweet spot $15–$100
**Price range**
**Incredible****$14.99–$67.44**
cheapest to priciest tracked listing — scored on the share inside $15–$100
**Market size**
**Great****$1.8M**
$1.8M/yr · 506K searches
**Growth**
**Okay****+15.4%**
90-day search growth — must beat 0% to launch
**Review moat**
**Okay****3,319.1**
avg incumbent reviews — the moat a new listing must climb
**Quality gap**
**Bad****4.6★**
avg incumbent rating — lower means beatable quality
**Competition**
**Bad****84%**
top-5 click share — a locked-up shelf
**Brand share**
**Bad****100%**
top-5 brand share — brand-locked demand
## **Is mthfr supplement profitable on Amazon?**
According to Flapen's Amazon United States niche tracking, mthfr supplement is a $1.8M/yr Amazon United States market (506K searches/yr). The top 5 brands hold 100% of demand. Verdict: Worth a look — 55/100.
Data updated Jul 28, 2026 · scored weekly · [~~How we score niches ~~](https://flapen.com/research/methodology)
## **mthfr supplement market size & sales**
Units sold, revenue, conversion and listing quality across the tracked shelf.
- **Units sold / yr**
- **50K–60K**
- avg 4,000–5,000/product
- **Revenue / yr**
- **$1.5M–$1.8M**
- units × avg price
- **Conversion rate**
- **12.0%**
- **Avg BSR**
- **#2,562**
- **Page quality**
- **0%**
- **Prime**
- **90%**
- **Sponsored**
- **100%**
- **Out of stock**
- **0.0%**
- **Avg brand age**
- **60 months**
- **Avg seller age**
- **157 days**
## **Competition: brands, sellers & click share**
The top 5 products capture 84% of clicks — a locked-up shelf that new listings rarely crack.
**Brands**
**4 **—flat
**Sellers**
**7**
**Top-5 brand share**
**100%**
Top 20: 100%
**Top-5 click share**
**84%**
Top 20: 100%
**Open market**
**0%**
- Triquetra Health73% - THORNE22% - C&D Jewelry3% - Micro Ingredients3%
## **mthfr supplement demand & seasonality**
Weekly Amazon search volume, last 104 weeks — +15.4% search growth over the last 90 days.
15K10KHoliday '24Spike '25Prime Day '25Spike '26 seasonSepDecMarJunAugNovMarMay
No pronounced peak months · busiest ÷ quietest = 1.3×
[**Open Trend **](https://flapen.com/research/us/health-household/mthfr-supplement/trend)
## **Top mthfr supplement search terms shoppers use**
The exact queries shoppers type, with yearly volume, growth and conversion.
- **mthfr supplement**94K/yr+23.0%8.7% conv. - **5-mthf**84K/yr+27.7%12.0% conv. - **triquetra**85K/yr-5.3%2.0% conv. - **5 mthf**58K/yr+22.6%10.3% conv. - **5mthf**39K/yr+26.0%9.6% conv. - **mthfr**36K/yr+30.4%7.6% conv. - **mthf**13K/yr+53.8%8.5% conv. - **thorne methylfolate**14K/yr-2.0%17.5% conv. - **mtfr supplement**8K/yr+36.8%5.8% conv. - **5 methylfolate supplement**7K/yr+31.9%8.4% conv. [**All search terms **](https://flapen.com/research/us/health-household/mthfr-supplement/search-terms)
## **Top mthfr supplement products & what they sell for**
Every tracked product — its share of the shelf, its review moat, and what it sells for.
Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
0%10%$181K20%$361K30%$542K40%$722K101001K10K Reviews — right = deep review moatMarket share (90d) ≈ est. sales
Beatable (≤4.3★) Contested Strong incumbent (>4.7★)
All 10 tracked products in this niche — three views at once, no toggling.
### **Top sellers**
by 90-day click share
[1**L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$21.67**4.6★9,407 rev](https://www.amazon.com/dp/B0938NKV1G) [2**THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health Fetal Development Nerve Health Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg**THORNE**$23.88**4.7★4,081 rev](https://www.amazon.com/dp/B00FY8IQ7C) [3**L Methyl Folate 15mg Plus Methyl B12 Cofactor Organic Berry Flavor High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms Vitamin B9 & B12 (1oz)**Triquetra Health**$21.87**4.5★5,924 rev](https://www.amazon.com/dp/B0B83PXLXW) [4**Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) Metabolically Active 5-MTHF Form Organic Berry Flavor Liquid Sublingual Form Mood Cognition Methylation Pregnancy (1oz)**Triquetra Health**$21.84**4.6★4,077 rev](https://www.amazon.com/dp/B0B83S4VLQ) [5**Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz**Triquetra Health**$19.20**4.5★2,493 rev](https://www.amazon.com/dp/B0DLCGKQMR)
**~~View all top sellers →~~**
### **Newest**
by launch date
[**Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil**Micro Ingredients**$28.48**289 rev1y ago](https://www.amazon.com/dp/B0F5S1V6ZQ) [**Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz**Triquetra Health**$19.20**2,493 rev1y ago](https://www.amazon.com/dp/B0DLCGKQMR) [**L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$17.83**4,077 rev1y ago](https://www.amazon.com/dp/B0DCZTJSL9) [**L Methyl Folate 15mg Plus Methyl B12 Cofactor Organic Berry Flavor High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms Vitamin B9 & B12 (1oz)**Triquetra Health**$21.87**5,924 rev4y ago](https://www.amazon.com/dp/B0B83PXLXW) [**Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) Metabolically Active 5-MTHF Form Organic Berry Flavor Liquid Sublingual Form Mood Cognition Methylation Pregnancy (1oz)**Triquetra Health**$21.84**4,077 rev4y ago](https://www.amazon.com/dp/B0B83S4VLQ)
**~~View all new products →~~**
### **Trending**
90-day click momentum
[**Irish Ring Claddagh Rings for Women. (Size 7) Stainless Steel - Lovers Heart Celtic Rings for Women with Triquetra Ring Jewelry Design - Irish Gifts (7)**C&D Jewelry**$14.99**4.4★**▲ 279%**](https://www.amazon.com/dp/B00654MN6Y) [**Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil**Micro Ingredients**$28.48**4.8★**▲ 57%**](https://www.amazon.com/dp/B0F5S1V6ZQ) [**L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$17.83**4.6★**▲ 51%**](https://www.amazon.com/dp/B0DCZTJSL9) [**L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$21.67**4.6★**▲ 16%**](https://www.amazon.com/dp/B0938NKV1G) [**Organic Kids L-Methylfolate + Methyl B12 Cofactor - MTHFR Sublingual Form - 5-MTHF Superior Form of Folate - Adjustable Dosing for All Ages - Mood Behavior Cognition - Organic Berry Flavor 1 Fl oz**Triquetra Health**$19.20**4.5★**— 1%**](https://www.amazon.com/dp/B0DLCGKQMR)
**~~View all trending →~~**
## **What reviews say buyers love and hate about mthfr supplement**
What buyers praise and complain about, mined from review topics.
### **What buyers love **
**Quality-Overall**17%
*“Quality and ease of use”*
**Taste-Overall**9%
*“Doesnt taste bad”*
**Vitamin**9%
*“Great vitamin”*
**Focus Enhancement**8%
*“feel like it improves my mood”*
**Energy Level**7%
*“Lots of Energy”*
**Efficiency**7%
*“Effective”*
**Advertised Vs Actual Product**6%
*“Just as advertised”*
**Value For Money**4%
*“Great value”*
**Ease Of Use**3%
*“Easy to use”*
**Dosage**3%
*“Great product when you get the right dosage”*
### **What buyers complain about **
**Functionality-Overall**10%
*“Doesn't do anything”*
**Side Effects**9%
*“had some strange side effects”*
**Dosage**8%
*“Unless you've been specifically instructed by a doctor to take this high of a dosage”*
**Taste-Overall**6%
*“It tastes terrible”*
**Vitamin**5%
*“Way too much Vitamin B9 and B12”*
**Value For Money**5%
*“The price is a little high”*
**Quality-Overall**4%
*“Its not as good as they make it seem”*
**Sleep Quality**3%
*“I also couldnt sleep”*
**Allergies**2%
*“Allergic”*
**Stress/Anxiety**2%
*“Seemed to cause anxiety”*
### **Top return reasons **
**Dosage**23%
**Functionality-Overall**14%
**Value For Money**9%
**Natural Ingredients**7%
**Vitamin**5%
**Vegan/Organic**5%
**Ease Of Use**5%
**Heart Health**5%
**Calcium**5%
**Quality-Overall**5%
## **Common mthfr supplement questions**
- **Is mthfr supplement profitable to sell on Amazon United States?**
- The niche generates $1.8M/yr across 10 tracked products. 90-day search growth is +15.4%. Flapen's verdict: Worth a look (55/100).
- **How competitive is the mthfr supplement niche?**
- 4 brands and 7 sellers compete. The top 5 products take 84% of clicks and top 5 brands hold 100% of demand.
- **What do buyers complain about in mthfr supplement?**
- Top complaints mined from reviews: Functionality-Overall, Side Effects, Dosage. The return rate is 0.0%.
- **When does demand for mthfr supplement peak?**
- Demand is steady year-round — the busiest month runs 1.3× the quietest.
- **What does it cost to enter the mthfr supplement niche?**
- Listings span $14.99–$67.44; the average listing price is $29.78 (sweet spot $15–$100). The average incumbent carries 3,319 reviews — the moat a new listing must climb.
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