---
title: "Diphenhydramine — $532K/yr Amazon US Niche (2026) - Flapen"
canonical_url: "https://flapen.com/research/us/health-household/diphenhydramine"
last_updated: "2026-08-11T09:03:52.699Z"
locale: en
meta:
description: "Niche score 43/100 · $532K/yr market · 533K searches/yr · $8.24 avg price. Doesn't clear our bar today. Data updated Jul 2026."
"og:description": "Niche score 43/100 · $532K/yr market · 533K searches/yr · $8.24 avg price. Doesn't clear our bar today. Data updated Jul 2026."
"og:title": "Diphenhydramine — $532K/yr Amazon US Niche (2026) - Flapen"
---
# **diphenhydramine**
**Skip it**
Prices mostly outside the sweet spot ($4.12–$10.33) — this niche doesn't clear our bar today.
Market size 61Growth 25Conversion 95Competition 24Returns 100Price range 0Avg price 23Brand share 35Review moat 19Quality gap 17
**Returns**
**Incredible****0.0%**
return rate — above 5% kills the launch gate
**Conversion**
**Incredible****12.1%**
search→purchase rate — share of searches ending in a sale
**Market size**
**Good****$532K**
$532K/yr · 533K searches
**Brand share**
**Okay****84%**
top-5 brand share — brands hold most of the demand
**Growth**
**Okay****+0.3%**
90-day search growth — must beat 0% to launch
**Competition**
**Bad****71%**
top-5 click share — a locked-up shelf
**Avg price**
**Bad****$8.24**
avg listing price — sweet spot $15–$100
**Review moat**
**Bad****15,029.8**
avg incumbent reviews — the moat a new listing must climb
**Quality gap**
**Bad****4.7★**
avg incumbent rating — lower means beatable quality
**Price range**
**Bad****$4.12–$10.33**
cheapest to priciest tracked listing — scored on the share inside $15–$100
According to Flapen's Amazon United States niche tracking, diphenhydramine is a $532K/yr Amazon United States market (533K searches/yr). The top 5 brands hold 84% of demand. Verdict: Skip it — 43/100.
Data updated Jul 11, 2026 · scored weekly · [~~How we score niches ~~](https://flapen.com/research/methodology)
## **diphenhydramine market data**
- **Units sold / yr**
- **60K–80K**
- avg 4,000–5,000/product
- **Revenue / yr**
- **$494K–$659K**
- units × avg price
- **Conversion rate**
- **12.1%**
- **Avg BSR**
- **#88**
- **Page quality**
- **0%**
- **Prime**
- **100%**
- **Sponsored**
- **80%**
- **Out of stock**
- **0.0%**
- **Avg brand age**
- **78 months**
- **Avg seller age**
- **150 days**
## **Competition & brand share**
The top 5 products capture 71% of clicks — a locked-up shelf that new listings rarely crack.
**Brands**
**11 **▲rising
**Sellers**
**60**
**Top-5 brand share**
**84%**
Top 20: 100%
**Top-5 click share**
**71%**
Top 20: 100%
**Open market**
**11%**
- Amazon Basic Care51% - HEALTH LFE11% - HealthA2Z10% - Generic7% - TIME-CAP LABS, INC.5% - ValuMeds4% - Open — no brand owns it (5 brands, 11%)
## **Demand & seasonality**
Weekly Amazon search volume, last 104 weeks — +0.3% search growth over the last 90 days.
10K6KSpike '25Prime Day '25 seasonSepDecMarJunAugNovMarMay
No pronounced peak months · busiest ÷ quietest = 1.3×
[**Open Trend **](https://flapen.com/research/us/health-household/diphenhydramine/trend)
## **Top diphenhydramine search terms**
- **diphenhydramine**249K/yr+0.7%10.6% conv. - **diphenhydramine 25mg**113K/yr+10.5%18.0% conv. - **generic benadryl**27K/yr+18.2%19.8% conv. - **amazon basic care**34K/yr-36.8%0.3% conv. - **amazon health**30K/yr-25.9%0.0% conv. - **diphenhydramine hcl**13K/yr+11.6%7.8% conv. - **diphenhydramine hcl 25 mg**8K/yr+79.0%14.1% conv. - **benadryl generic**7K/yr+28.0%19.2% conv. - **amazon basics medicine**10K/yr-10.2%0.5% conv. - **difenhidramina**8K/yr+30.1%4.4% conv. [**All search terms **](https://flapen.com/research/us/health-household/diphenhydramine/search-terms)
## **Top diphenhydramine products on Amazon**
Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
0%10%$53K20%$106K30%$160K40%$213K1001K10K100K Reviews — right = deep review moatMarket share (90d) ≈ est. sales
Beatable (≤4.3★) Contested Strong incumbent (>4.7★)
All 15 tracked products in this niche — three views at once, no toggling.
### **Top sellers**
by 90-day click share
[1**Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies Mini-Tabs 100 Count**Amazon Basic Care**$4.12**4.8★54,786 rev](https://www.amazon.com/dp/B07HD8SFNT) [2**Amazon Basic Care Complete Allergy Relief Diphenhydramine HCl 25 mg Easy to Swallow Mini-Tabs Relieves Sneezing Itchy Eyes Runny Nose Itchy Throat 400 Count**Amazon Basic Care**$8.12**4.8★54,786 rev](https://www.amazon.com/dp/B074F19XB8) [3**HEALTH LFE Allergy Relief Medicine Diphenhydramine HCl Caplets 25 mg | Children and Adults | Relieves Sneezing Runny Nose Hay Fever Symptoms Itchy Eyes and Throat (Large 1000 Count)**HEALTH LFE**$10.12**4.8★2,715 rev](https://www.amazon.com/dp/B0977CZ4Q3) [4**MedPlus Allergy Relief Medicine Diphenhydramine HCl 25 mg 1000 Tablets Antihistamine Relief for Indoor & Outdoor Allergies Made in USA**Generic**$10.33**4.8★1,330 rev](https://www.amazon.com/dp/B0B86KXZR3) [5**TIME-Cap Labs 650 Caplets Diphenhydramine HCl 25mg Allergy Relief Antihistamine for Adults Helps Relieve Sneezing Runny Nose Itchy Watery Eyes & Itchy Throat**TIME-CAP LABS, INC.**$8.77**4.8★5,236 rev](https://www.amazon.com/dp/B09QX4MB78)
**~~View all top sellers →~~**
### **Newest**
by launch date
[**Berkley Jensen Allergy Relief Tablets 25mg Diphenhydramine HCI 600 Count**berkley jensen**$8.00**189 rev5mo ago](https://www.amazon.com/dp/B0GL6ZQSDV) [**GoodMeds Allergy Medicine Antihistamine Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes Runny Nose Sneezing (25 mg 600 Tablets)**GoodMeds**$9.60**534 rev6mo ago](https://www.amazon.com/dp/B0GF3BCLGY) [**HEALTH LFE HealthLife Sleep Aid (Diphenhydramine HCl Caplets 25 mg Blue) 300 Count**HEALTH LFE**$7.03**483 rev3y ago](https://www.amazon.com/dp/B0C3JJJF9N) [**MedPlus Allergy Relief Medicine Diphenhydramine HCl 25 mg 1000 Tablets Antihistamine Relief for Indoor & Outdoor Allergies Made in USA**Generic**$10.33**1,330 rev3y ago](https://www.amazon.com/dp/B0B86KXZR3) [**HealthA2Z Allergy Relief | Diphenhydramine HCL 25mg | Antihistamine | Relief from Itchy Throat Sneezing Runny Noses | Indoor & Outdoors Allergies (200 Caplets (Pack of 1))**HealthA2Z**$5.45**2,441 rev4y ago](https://www.amazon.com/dp/B09YJY6QSW)
**~~View all new products →~~**
### **Trending**
90-day click momentum
[**Safrel Allergy Relief Medication 25mg Diphenhydramine HCl Antihistamine for Sneezing Runny Nose Itchy Eyes and Throat Indoor and Outdoor Allergies (1000 Count)**Safrel**$10.11**4.7★**▲ 207%**](https://www.amazon.com/dp/B08TQ65Y2R) [**GoodMeds Allergy Medicine Antihistamine Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes Runny Nose Sneezing (25 mg 600 Tablets)**GoodMeds**$9.60**4.8★**▲ 171%**](https://www.amazon.com/dp/B0GF3BCLGY) [**Berkley Jensen Allergy Relief Tablets 25mg Diphenhydramine HCI 600 Count**berkley jensen**$8.00**4.6★**▲ 94%**](https://www.amazon.com/dp/B0GL6ZQSDV) [**HEALTH LFE HealthLife Sleep Aid (Diphenhydramine HCl Caplets 25 mg Blue) 300 Count**HEALTH LFE**$7.03**4.6★**▲ 70%**](https://www.amazon.com/dp/B0C3JJJF9N) [**MedPlus Allergy Relief Medicine Diphenhydramine HCl 25 mg 1000 Tablets Antihistamine Relief for Indoor & Outdoor Allergies Made in USA**Generic**$10.33**4.8★**▲ 19%**](https://www.amazon.com/dp/B0B86KXZR3)
**~~View all trending →~~**
## **What buyers say about diphenhydramine**
What buyers praise and complain about, mined from review topics.
### **What buyers love **
**Value For Money**26%
*“much less expensive”*
**Sleep Quality**14%
*“Helps me sleep”*
**Allergies**13%
*“Good for allergies”*
**Quality-Overall**10%
*“the tablets have been consistent in quality”*
**Efficiency**9%
*“Does work”*
**Advertised Vs Actual Product**8%
*“As advertised”*
**Dosage**3%
*“Perfect dosage”*
**Ease Of Chewing/Swallowing**2%
*“I'm really glad I got what I ordered, because, although a little bigger, they're much easier to swallow and there's no horrible taste like the Tablets have”*
**Ease Of Use**1%
*“Easy to use”*
**Sinus Relief**1%
*“Helps with sinus and allergy issues”*
### **What buyers complain about **
**Sleep Quality**20%
*“Did not help me sleep”*
**Allergies**15%
*“having allergic reaction to something”*
**Functionality-Overall**12%
*“Doesnt work well”*
**Dosage**6%
*“This dosage is not easy to find locally”*
**Value For Money**4%
*“cheaper”*
**Strength**3%
*“Not as strong as needed”*
**Taste-Overall**2%
*“found them to have a strong chemical taste”*
**Side Effects**2%
*“It literally makes me nauseous”*
**Ingredients-Overall**2%
*“The bottle is a bit more barebones than Equate”*
**Size-Overall**2%
*“Very small”*
## **Common questions**
- **Is diphenhydramine profitable to sell on Amazon United States?**
- The niche generates $532K/yr across 15 tracked products. 1 of 2 products launched in the last 360 days are still selling. 90-day search growth is +0.3%. Flapen's verdict: Skip it (43/100).
- **How competitive is the diphenhydramine niche?**
- 11 brands and 60 sellers compete. The top 5 products take 71% of clicks and top 5 brands hold 84% of demand.
- **What do buyers complain about in diphenhydramine?**
- Top complaints mined from reviews: Sleep Quality, Allergies, Functionality-Overall. The return rate is 0.0%.
- **When does demand for diphenhydramine peak?**
- Demand is steady year-round — the busiest month runs 1.3× the quietest.
- **What does it cost to enter the diphenhydramine niche?**
- Listings span $4.12–$10.33; the average listing price is $8.24 (sweet spot $15–$100). The average incumbent carries 15,030 reviews — the moat a new listing must climb.
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