---
title: "Antidepressants — $309K/yr Amazon US Niche (2026) - Flapen"
canonical_url: "https://flapen.com/research/us/health-household/antidepressants"
last_updated: "2026-08-09T08:08:32.800Z"
locale: en
meta:
description: "Niche score 49/100 · $309K/yr market · 183K searches/yr · $17.96 avg price. Doesn't clear our bar today. Data updated Jul 2026."
"og:description": "Niche score 49/100 · $309K/yr market · 183K searches/yr · $17.96 avg price. Doesn't clear our bar today. Data updated Jul 2026."
"og:title": "Antidepressants — $309K/yr Amazon US Niche (2026) - Flapen"
---
# **antidepressants**
**Skip it**
Brand-locked demand (top 5 brands take 98% of clicks) — this niche doesn't clear our bar today.
Market size 51Growth 23Conversion 85Competition 18Returns 100Price range 79Avg price 82Brand share 4Review moat 24Quality gap 65
**Returns**
**Incredible****0.0%**
return rate — above 5% kills the launch gate
**Conversion**
**Great****9.4%**
search→purchase rate — share of searches ending in a sale
**Avg price**
**Great****$17.96**
avg listing price — sweet spot $15–$100
**Price range**
**Great****$8.54–$41.83**
cheapest to priciest tracked listing — scored on the share inside $15–$100
**Quality gap**
**Good****4.4★**
avg incumbent rating — lower means beatable quality
**Market size**
**Good****$309K**
$309K/yr · 183K searches
**Review moat**
**Bad****5,983.07**
avg incumbent reviews — the moat a new listing must climb
**Growth**
**Bad****-3.6%**
90-day search growth — must beat 0% to launch
**Competition**
**Bad****78%**
top-5 click share — a locked-up shelf
**Brand share**
**Bad****98%**
top-5 brand share — brand-locked demand
According to Flapen's Amazon United States niche tracking, antidepressants is a $309K/yr Amazon United States market (183K searches/yr). The top 5 brands hold 98% of demand. Demand peaks in Sep. Verdict: Skip it — 49/100.
Data updated Jul 10, 2026 · scored weekly · [~~How we score niches ~~](https://flapen.com/research/methodology)
## **antidepressants market data**
- **Units sold / yr**
- **15K–20K**
- avg 1,250–1,500/product
- **Revenue / yr**
- **$269K–$359K**
- units × avg price
- **Conversion rate**
- **9.4%**
- **Avg BSR**
- **#142**
- **Page quality**
- **0%**
- **Prime**
- **100%**
- **Sponsored**
- **100%**
- **Out of stock**
- **0.0%**
- **Avg brand age**
- **61 months**
- **Avg seller age**
- **157 days**
## **Competition & brand share**
The top 5 products capture 78% of clicks — a locked-up shelf that new listings rarely crack.
**Brands**
**6 **▼falling
**Sellers**
**618**
**Top-5 brand share**
**98%**
Top 20: 100%
**Top-5 click share**
**78%**
Top 20: 100%
**Open market**
**0%**
- Boiron74% - LifeSeasons9% - Laki Naturals7% - OLLY5% - Futurebiotics3% - Happy Healthy Hippie2% - Open — no brand owns it (0%)
## **Demand & seasonality**
Weekly Amazon search volume, last 104 weeks — -3.6% search growth over the last 90 days.
10K6KSpike '24Spike '25Spike '26 seasonSepDecMarJunAugNovMarMay
Peak months: Sep · busiest ÷ quietest = 3.5×
[**Open Trend **](https://flapen.com/research/us/health-household/antidepressants/trend)
## **Top antidepressants search terms**
- **stress calm**34K/yr+0.8%14.0% conv. - **antidepressants**24K/yr-4.8%1.1% conv. - **boiron stress calm**17K/yr-12.1%17.2% conv. - **anti depressant**15K/yr-8.5%1.4% conv. - **stress calm boiron**10K/yr+20.2%19.1% conv. - **flight anxiety essentials**11K/yr-18.2%1.7% conv. - **antidepressants for women**11K/yr-3.4%1.1% conv. - **clordiazepoxido cubano**9K/yr-24.1%2.8% conv. - **sedative**6K/yr+49.3%0.7% conv. - **homeopathic anxiety relief**6K/yr+8.7%6.1% conv. [**All search terms **](https://flapen.com/research/us/health-household/antidepressants/search-terms)
## **Top antidepressants products on Amazon**
Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
0%10%$31K20%$62K30%$93K40%$124K101001K10K100K Reviews — right = deep review moatMarket share (90d) ≈ est. sales
Beatable (≤4.3★) Contested Strong incumbent (>4.7★)
All 14 tracked products in this niche — three views at once, no toggling.
### **Top sellers**
by 90-day click share
[1**Boiron StressCalm Tablets for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - 60 Count**Boiron**$8.54**4.3★7,644 rev](https://www.amazon.com/dp/B08VYWSVVF) [2**Boiron StressCalm Tablets for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - 120 Count**Boiron**$15.73**4.3★7,644 rev](https://www.amazon.com/dp/B09JT5SWQV) [3**Boiron StressCalm On The Go for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - 2 Count (160 Pellets)**Boiron**$9.30**4.3★1,668 rev](https://www.amazon.com/dp/B0B9DQQKLG) [4**Boiron StressCalm Tabs - 100 Count for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - Convenient Stress Calm Meltaway Tablets**Boiron**$18.20**4.9★40 rev](https://www.amazon.com/dp/B0DTFLWQR7) [5**Laki Naturals Fly Calm Patch (1 Count Pack of 8) - Relax Nerves Support Stress - Natural Ingredients to Support Airplane Stress - Calm Your Fear of Flying Naturally**Laki Naturals**$15.54**4.0★552 rev](https://www.amazon.com/dp/B0CCSWWDK7)
**~~View all top sellers →~~**
### **Newest**
by launch date
[**Boiron StressCalm Tabs - 100 Count for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - Convenient Stress Calm Meltaway Tablets**Boiron**$18.20**40 rev1y ago](https://www.amazon.com/dp/B0DTFLWQR7) [**Futurebiotics Ashwagandha Extra Strength Stress & Mood Support 100 Capsules**Futurebiotics**$9.75**13,430 rev2y ago](https://www.amazon.com/dp/B0CQMHSPDV) [**Anxie-T Plus - Extra Strength Stress Relief Supplement - Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha Kava Kava GABA & L-Theanine - 60 Capsules**LifeSeasons**$41.83**774 rev2y ago](https://www.amazon.com/dp/B0CN9L54YC) [**Futurebiotics Chill Pill + Ashwagandha Rhodiola St. Johns Wort & L-Theanine - Non-GMO 120 Vegetarian Tablets**Futurebiotics**$9.94**2,015 rev2y ago](https://www.amazon.com/dp/B0CGJJC21R) [**Laki Naturals Fly Calm Patch (1 Count Pack of 8) - Relax Nerves Support Stress - Natural Ingredients to Support Airplane Stress - Calm Your Fear of Flying Naturally**Laki Naturals**$15.54**552 rev2y ago](https://www.amazon.com/dp/B0CCSWWDK7)
**~~View all new products →~~**
### **Trending**
90-day click momentum
[**Boiron StressCalm Tabs - 100 Count for Relief of Stress Anxiousness Nervousness Irritability and Fatigue - Convenient Stress Calm Meltaway Tablets**Boiron**$18.20**4.9★**▲ 106%**](https://www.amazon.com/dp/B0DTFLWQR7) [**OLLY Hello Happy Gummy Worms Mood Support Gummies For Adults * Saffron Extract Vitamin D Tropical Zing Flavored 30 Day Supply - 60 Count**OLLY**$16.52**4.4★**▲ 56%**](https://www.amazon.com/dp/B092L9WWC8) [**OLLY Goodbye Stress Gummy GABA L-Theanine Lemon Balm Stress Relief Supplement Berry - 42 Count**OLLY**$11.58**4.4★**▲ 20%**](https://www.amazon.com/dp/B01M1HYRNJ) [**Laki Naturals Fly Calm Patch (1 Count Pack of 8) - Relax Nerves Support Stress - Natural Ingredients to Support Airplane Stress - Calm Your Fear of Flying Naturally**Laki Naturals**$15.54**4.0★**▲ 12%**](https://www.amazon.com/dp/B0CCSWWDK7) [**Anxie-T Plus - Extra Strength Stress Relief Supplement - Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha Kava Kava GABA & L-Theanine - 60 Capsules**LifeSeasons**$41.83**4.2★**— 9%**](https://www.amazon.com/dp/B0CN9L54YC)
**~~View all trending →~~**
## **What buyers say about antidepressants**
What buyers praise and complain about, mined from review topics.
### **What buyers love **
**Stress/Anxiety**23%
*“Anxiety relief”*
**Quality-Overall**9%
*“Excellent product”*
**Sleep Quality**8%
*“Helps with sleep”*
**Efficiency**8%
*“worked well for my needs”*
**Soothing Effect**5%
*“Soothing”*
**Taste-Overall**5%
*“Great taste, help with mood boosting”*
**Side Effects**4%
*“Most of my symptoms are gone or significantly reduced”*
**Focus Enhancement**3%
*“helps you focus”*
**Value For Money**3%
*“Good product for the price”*
**Advertised Vs Actual Product**3%
*“Works as advertised”*
### **What buyers complain about **
**Functionality-Overall**17%
*“Did not seem to be effective”*
**Stress/Anxiety**13%
*“DOES NOT HELP STRESS”*
**Side Effects**8%
*“Side effects were scary”*
**Taste-Overall**7%
*“Bad Aftertaste”*
**Sleep Quality**6%
*“I struggle with sleep”*
**Value For Money**5%
*“Waste of money”*
**Dosage**3%
*“The 5 pill dose is too much for me”*
**Ingredients-Overall**2%
*“Could be because my body isnt used to the ingredients”*
**Heart Health**2%
*“Caused heart arrhythmia”*
**Allergies**2%
*“He was becoming irritated”*
### **Top return reasons **
**Functionality-Overall**27%
**Magnesium**9%
**Value For Money**9%
**Ingredients-Overall**9%
**Fever Relief**9%
**Dosage**9%
**Advertised Vs Actual Product**9%
**Vitamin**9%
**Moist/Dry**9%
## **Common questions**
- **Is antidepressants profitable to sell on Amazon United States?**
- The niche generates $309K/yr across 14 tracked products. 90-day search growth is -3.6%. Flapen's verdict: Skip it (49/100).
- **How competitive is the antidepressants niche?**
- 6 brands and 618 sellers compete. The top 5 products take 78% of clicks and top 5 brands hold 98% of demand.
- **What do buyers complain about in antidepressants?**
- Top complaints mined from reviews: Functionality-Overall, Stress/Anxiety, Side Effects. The return rate is 0.0%.
- **When does demand for antidepressants peak?**
- Demand peaks in Sep; the busiest month runs 3.5× the quietest.
- **What does it cost to enter the antidepressants niche?**
- Listings span $8.54–$41.83; the average listing price is $17.96 (sweet spot $15–$100). The average incumbent carries 5,983 reviews — the moat a new listing must climb.
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