---
title: "5 Mthf Plus B12 — $37K/yr Amazon US Niche (2026) - Flapen"
canonical_url: "https://flapen.com/research/us/health-household/5-mthf-plus-b12"
last_updated: "2026-08-09T07:14:26.691Z"
locale: en
meta:
description: "Niche score 47/100 · $37K/yr market · 12K searches/yr · $27.51 avg price. Doesn't clear our bar today. Data updated Jul 2026."
"og:description": "Niche score 47/100 · $37K/yr market · 12K searches/yr · $27.51 avg price. Doesn't clear our bar today. Data updated Jul 2026."
"og:title": "5 Mthf Plus B12 — $37K/yr Amazon US Niche (2026) - Flapen"
---
# **5 mthf plus b12**
**Skip it**
A small market ($37K/yr) — this niche doesn't clear our bar today.
Market size 9Growth 54Conversion 90Competition 25Returns 100Price range 91Avg price 95Brand share 16Review moat 36Quality gap 23
**Returns**
**Incredible****0.0%**
return rate — above 5% kills the launch gate
**Avg price**
**Incredible****$27.51**
avg listing price — sweet spot $15–$100
**Price range**
**Great****$11.10–$88.17**
cheapest to priciest tracked listing — scored on the share inside $15–$100
**Conversion**
**Great****10.8%**
search→purchase rate — share of searches ending in a sale
**Growth**
**Good****+26.3%**
90-day search growth — must beat 0% to launch
**Review moat**
**Okay****2,883.08**
avg incumbent reviews — the moat a new listing must climb
**Competition**
**Bad****71%**
top-5 click share — a locked-up shelf
**Quality gap**
**Bad****4.6★**
avg incumbent rating — lower means beatable quality
**Brand share**
**Bad****94%**
top-5 brand share — brand-locked demand
**Market size**
**Bad****$37K**
$37K/yr · 12K searches
According to Flapen's Amazon United States niche tracking, 5 mthf plus b12 is a $37K/yr Amazon United States market (12K searches/yr). The top 5 brands hold 94% of demand. Demand peaks in Jan–Feb–Dec. Verdict: Skip it — 47/100.
Data updated Jul 28, 2026 · scored weekly · [~~How we score niches ~~](https://flapen.com/research/methodology)
## **5 mthf plus b12 market data**
- **Units sold / yr**
- **2K–2K**
- avg 100–250/product
- **Revenue / yr**
- **$41K–$55K**
- units × avg price
- **Conversion rate**
- **10.8%**
- **Avg BSR**
- **#82**
- **Page quality**
- **0%**
- **Prime**
- **100%**
- **Sponsored**
- **100%**
- **Out of stock**
- **0.0%**
- **Avg brand age**
- **67 months**
- **Avg seller age**
- **167 days**
## **Competition & brand share**
The top 5 products capture 71% of clicks — a locked-up shelf that new listings rarely crack.
**Brands**
**8 **▲rising
**Sellers**
**534**
**Top-5 brand share**
**94%**
Top 20: 100%
**Top-5 click share**
**71%**
Top 20: 100%
**Open market**
**4%**
- Triquetra Health58% - Designs for Health16% - Nutricost10% - THORNE5% - Vocks4% - Pure Encapsulations3% - Open — no brand owns it (2 brands, 4%)
## **Demand & seasonality**
Weekly Amazon search volume, last 98 weeks — +26.3% search growth over the last 90 days.
3K2KSpike '24Holiday '24Spike '25Spike '26 seasonDecMarJunAugNovMarMay
Peak months: Jan, Feb, Dec · busiest ÷ quietest = 5.9×
[**Open Trend **](https://flapen.com/research/us/health-household/5-mthf-plus-b12/trend)
## **Top 5 mthf plus b12 search terms**
- **5mthf supplement plus b12**7K/yr+37.0%9.3% conv. - **l-5-mthf**4K/yr-17.1%11.9% conv. - **methylated folic acid and b12**2K/yr+159.0%10.7% conv. [**All search terms **](https://flapen.com/research/us/health-household/5-mthf-plus-b12/search-terms)
## **Top 5 mthf plus b12 products on Amazon**
Each bubble is one product — market share against review moat; bubble size tracks estimated sales, color grades how beatable the incumbent looks.
0%10%$4K20%$7K30%$11K40%$15K101001K10K Reviews — right = deep review moatMarket share (90d) ≈ est. sales
Beatable (≤4.3★) Contested Strong incumbent (>4.7★)
All 13 tracked products in this niche — three views at once, no toggling.
### **Top sellers**
by 90-day click share
[1**L Methyl Folate 15mg Plus Methyl B12 Cofactor High Potency Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$21.67**4.6★9,407 rev](https://www.amazon.com/dp/B0938NKV1G) [2**Designs for Health L 5-MTHF - Quatrefolic L Methylfolate Supplement 1mg (1700mcg DFE) - Methylated Folate Supplement for Women & Men - Supports Methylation - Non-GMO Gluten Free (120 Capsules)**Designs for Health**$55.43**4.6★293 rev](https://www.amazon.com/dp/B004D3Z2QC) [3**L Methyl Folate 15mg Plus Methyl B12 Cofactor Organic Berry Flavor High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood Methylation Cognition Bioactive Forms Vitamin B9 & B12 (1oz)**Triquetra Health**$21.87**4.5★5,924 rev](https://www.amazon.com/dp/B0B83PXLXW) [4**Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) Metabolically Active 5-MTHF Form Organic Berry Flavor Liquid Sublingual Form Mood Cognition Methylation Pregnancy (1oz)**Triquetra Health**$21.84**4.6★4,077 rev](https://www.amazon.com/dp/B0B83S4VLQ) [5**L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$17.83**4.6★4,077 rev](https://www.amazon.com/dp/B0DCZTJSL9)
**~~View all top sellers →~~**
### **Newest**
by launch date
[**Vocks L Methylfolate 15mg | 5-MTHF + Methyl B12 | High Potency Methylfolate Supplement | Active Methylated Folate Vitamin B9 | MTHFR Supplement| Folate Supplement for Women & Men | 90 Capsules**Vocks**$12.45**97 rev5mo ago](https://www.amazon.com/dp/B0GPZLTB3D) [**Nutricost Methylated Vitamin B12 + Folate Supplement (2 000 mcg) 120 Caps**Nutricost**$11.10**154 rev11mo ago](https://www.amazon.com/dp/B0FNFR1MPT) [**Micro Ingredients L Methylfolate 15mg 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil**Micro Ingredients**$28.48**289 rev1y ago](https://www.amazon.com/dp/B0F5S1V6ZQ) [**L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$17.83**4,077 rev1y ago](https://www.amazon.com/dp/B0DCZTJSL9) [**Nutricost L-Methylfolate 15mg 120 Capsules (5-MTHF) Gluten-Free Vegan**Nutricost**$19.72**530 rev2y ago](https://www.amazon.com/dp/B0CW3KHD4Z)
**~~View all new products →~~**
### **Trending**
90-day click momentum
[**Vocks L Methylfolate 15mg | 5-MTHF + Methyl B12 | High Potency Methylfolate Supplement | Active Methylated Folate Vitamin B9 | MTHFR Supplement| Folate Supplement for Women & Men | 90 Capsules**Vocks**$12.45**4.5★**▲ 406%**](https://www.amazon.com/dp/B0GPZLTB3D) [**Nutricost Methylated Vitamin B12 + Folate Supplement (2 000 mcg) 120 Caps**Nutricost**$11.10**4.7★**▲ 286%**](https://www.amazon.com/dp/B0FNFR1MPT) [**L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor Active 5-MTHF Form - Supports Mood Methylation Cognition Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules 60 Servings)**Triquetra Health**$17.83**4.6★**▲ 138%**](https://www.amazon.com/dp/B0DCZTJSL9) [**Jarrow Formulas Methyl B-12 & Methyl Folate Bioactive Vitamin B9 & Vitamin B12 Supplement Supports Cellular Energy Production Healthy Brain Function & Metabolism 100 Chewable Tablets 100 Servings**Jarrow Formulas**$13.68**4.6★**▲ 42%**](https://www.amazon.com/dp/B01IJR5VM2) [**Nutricost L-Methylfolate 15mg 120 Capsules (5-MTHF) Gluten-Free Vegan**Nutricost**$19.72**4.7★**▲ 39%**](https://www.amazon.com/dp/B0CW3KHD4Z)
**~~View all trending →~~**
## **What buyers say about 5 mthf plus b12**
What buyers praise and complain about, mined from review topics.
### **What buyers love **
**Quality-Overall**17%
*“Quality and ease of use”*
**Taste-Overall**9%
*“Doesnt taste bad”*
**Vitamin**9%
*“Natural vitamin”*
**Focus Enhancement**7%
*“helps with focus”*
**Energy Level**7%
*“Lots of Energy”*
**Efficiency**6%
*“Effective”*
**Advertised Vs Actual Product**5%
*“Just as advertised”*
**Value For Money**4%
*“Good value”*
**Ease Of Use**3%
*“Easy to use”*
**Dosage**3%
*“Easy dosages”*
### **What buyers complain about **
**Functionality-Overall**10%
*“Doesn't do anything”*
**Side Effects**9%
*“had some strange side effects”*
**Dosage**8%
*“The dose on this is a little too high”*
**Taste-Overall**6%
*“It tastes terrible”*
**Vitamin**4%
*“Way too much Vitamin B9 and B12”*
**Quality-Overall**4%
*“Its not as good as they make it seem”*
**Value For Money**3%
*“A bit expensive”*
**Sleep Quality**3%
*“I also couldnt sleep”*
**Advertised Vs Actual Product**2%
*“The advertisements are misleading”*
**Stress/Anxiety**2%
*“Seemed to cause anxiety”*
### **Top return reasons **
**Dosage**26%
**Functionality-Overall**17%
**Advertised Vs Actual Product**9%
**Value For Money**9%
**Natural Ingredients**7%
**Product Condition**4%
**Quality-Overall**4%
**Side Effects**4%
**Calcium**4%
**Vegan/Organic**4%
## **Common questions**
- **Is 5 mthf plus b12 profitable to sell on Amazon United States?**
- The niche generates $37K/yr across 13 tracked products. 2 of 2 products launched in the last 360 days are still selling. 90-day search growth is +26.3%. Flapen's verdict: Skip it (47/100).
- **How competitive is the 5 mthf plus b12 niche?**
- 8 brands and 534 sellers compete. The top 5 products take 71% of clicks and top 5 brands hold 94% of demand.
- **What do buyers complain about in 5 mthf plus b12?**
- Top complaints mined from reviews: Functionality-Overall, Side Effects, Dosage. The return rate is 0.0%.
- **When does demand for 5 mthf plus b12 peak?**
- Demand peaks in Jan–Feb–Dec; the busiest month runs 5.9× the quietest.
- **What does it cost to enter the 5 mthf plus b12 niche?**
- Listings span $11.10–$88.17; the average listing price is $27.51 (sweet spot $15–$100). The average incumbent carries 2,883 reviews — the moat a new listing must climb.
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